Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3410267..3410885 Replicon chromosome
Accession NZ_CP040927
Organism Escherichia coli strain YY76-1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag FH040_RS16595 Protein ID WP_001291435.1
Coordinates 3410667..3410885 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag FH040_RS16590 Protein ID WP_000344800.1
Coordinates 3410267..3410641 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH040_RS16580 3405356..3406549 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FH040_RS16585 3406572..3409721 + 3150 WP_113402280.1 efflux RND transporter permease AcrB -
FH040_RS16590 3410267..3410641 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
FH040_RS16595 3410667..3410885 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
FH040_RS16600 3411057..3411608 + 552 WP_000102564.1 maltose O-acetyltransferase -
FH040_RS16605 3411724..3412194 + 471 WP_000136192.1 YlaC family protein -
FH040_RS16610 3412358..3413908 + 1551 WP_063501968.1 cyclic-guanylate-specific phosphodiesterase PdeB -
FH040_RS16615 3413950..3414303 - 354 WP_000878140.1 DUF1428 domain-containing protein -
FH040_RS16625 3414682..3414993 + 312 WP_000409911.1 MGMT family protein -
FH040_RS16630 3415024..3415596 - 573 WP_113402281.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T127291 WP_001291435.1 NZ_CP040927:3410667-3410885 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T127291 NZ_CP040927:3410667-3410885 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT127291 WP_000344800.1 NZ_CP040927:3410267-3410641 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT127291 NZ_CP040927:3410267-3410641 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References