Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4119089..4119652 Replicon chromosome
Accession NZ_CP040915
Organism Georgenia sp. Z443

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FE374_RS18785 Protein ID WP_139931716.1
Coordinates 4119089..4119397 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FE374_RS18790 Protein ID WP_139931064.1
Coordinates 4119419..4119652 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE374_RS18760 4114517..4115764 + 1248 WP_139931715.1 RNA polymerase sigma factor -
FE374_RS18765 4115789..4116148 - 360 WP_139931060.1 hypothetical protein -
FE374_RS18770 4116239..4116846 + 608 Protein_3698 alpha/beta fold hydrolase -
FE374_RS18775 4116871..4117179 - 309 Protein_3699 DUF4180 domain-containing protein -
FE374_RS18780 4117268..4118926 - 1659 WP_139931062.1 FAD-dependent oxidoreductase -
FE374_RS18785 4119089..4119397 - 309 WP_139931716.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FE374_RS18790 4119419..4119652 - 234 WP_139931064.1 ribbon-helix-helix domain-containing protein Antitoxin
FE374_RS18795 4119795..4120415 + 621 WP_139931066.1 GyrI-like domain-containing protein -
FE374_RS18800 4120443..4120868 - 426 WP_139931068.1 NAD(+)--rifampin ADP-ribosyltransferase -
FE374_RS18805 4120947..4122344 + 1398 WP_139931070.1 DNA photolyase family protein -
FE374_RS18810 4122579..4123205 + 627 WP_139931072.1 DUF1349 domain-containing protein -
FE374_RS18815 4123354..4124058 - 705 WP_139931074.1 L-ribulose-5-phosphate 4-epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 10941.67 Da        Isoelectric Point: 8.0735

>T127226 WP_139931716.1 NZ_CP040915:c4119397-4119089 [Georgenia sp. Z443]
MHLDKARPAVVLTREAARSAMTKVTVAPVTSTIKGLTSEVRLGPHNGLDHECVASLDNVVTVPSQLVGRTIGFLTADQEK
QLARAVVLAYDLDLPLLRADRA

Download         Length: 309 bp

>T127226 NZ_CP040915:c4119397-4119089 [Georgenia sp. Z443]
ATGCACCTCGACAAGGCCCGACCAGCCGTCGTGCTCACTCGTGAAGCAGCCCGCTCGGCAATGACCAAGGTCACTGTCGC
ACCCGTCACCTCCACCATCAAGGGCCTGACTAGCGAGGTCCGGCTGGGCCCGCACAACGGACTCGACCACGAGTGCGTGG
CCTCGCTCGACAACGTCGTCACCGTCCCCTCGCAACTGGTCGGACGCACGATCGGCTTCTTGACCGCAGACCAGGAGAAG
CAGCTCGCCCGGGCCGTCGTGCTGGCATATGACCTCGACTTGCCACTGCTTCGCGCGGACCGCGCCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8335.45 Da        Isoelectric Point: 4.2821

>AT127226 WP_139931064.1 NZ_CP040915:c4119652-4119419 [Georgenia sp. Z443]
VSTQIAVRLPDEMVAFLDRAVASGKATSRASLVASALEREMRLLLAEQDAASLREKGPADDLDPLVNWTVGRVDLEE

Download         Length: 234 bp

>AT127226 NZ_CP040915:c4119652-4119419 [Georgenia sp. Z443]
GTGAGCACCCAGATCGCCGTCCGGCTCCCCGACGAGATGGTCGCCTTCCTCGACCGAGCCGTGGCCTCCGGCAAGGCCAC
GAGTCGTGCCAGCCTGGTTGCCAGCGCCCTGGAGCGCGAGATGCGGCTGCTCCTCGCAGAGCAGGACGCTGCCAGTCTTC
GAGAGAAGGGACCGGCGGACGACCTCGATCCACTCGTGAACTGGACCGTAGGCCGGGTCGACCTCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References