Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 3969314..3969960 Replicon chromosome
Accession NZ_CP040915
Organism Georgenia sp. Z443

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FE374_RS18085 Protein ID WP_139930832.1
Coordinates 3969314..3969727 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FE374_RS18090 Protein ID WP_139930834.1
Coordinates 3969724..3969960 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FE374_RS18065 3964343..3965896 + 1554 WP_139930826.1 hypothetical protein -
FE374_RS18070 3966188..3966469 + 282 WP_139930828.1 metal-sensitive transcriptional regulator -
FE374_RS18075 3966499..3966744 + 246 WP_139930830.1 heavy-metal-associated domain-containing protein -
FE374_RS18080 3966871..3969228 + 2358 WP_139931698.1 heavy metal translocating P-type ATPase -
FE374_RS18085 3969314..3969727 - 414 WP_139930832.1 type II toxin-antitoxin system VapC family toxin Toxin
FE374_RS18090 3969724..3969960 - 237 WP_139930834.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FE374_RS18095 3970163..3970774 + 612 WP_139930836.1 hypothetical protein -
FE374_RS18100 3970814..3972820 + 2007 WP_139930838.1 GAF domain-containing sensor histidine kinase -
FE374_RS18105 3972817..3973449 + 633 WP_139930840.1 response regulator transcription factor -
FE374_RS18110 3973470..3974158 - 689 Protein_3561 HAD family phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-123)

Antitoxin

SpoVT-AbrB domain

(3-42)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14313.45 Da        Isoelectric Point: 9.7360

>T127225 WP_139930832.1 NZ_CP040915:c3969727-3969314 [Georgenia sp. Z443]
MSAPLALDTSVAIPLLVQSHSAHQLVTRWWDGRDVALSGHALAETYSVLTRLPGDLRVSPANAARLLRERFGPPLLLRPG
TAARLPDVLSRADVAGGAVYDALVALAAAENGATLATRDARAKGTYEVVGARVIVVG

Download         Length: 414 bp

>T127225 NZ_CP040915:c3969727-3969314 [Georgenia sp. Z443]
ATGAGCGCGCCGCTCGCGCTCGACACCAGCGTCGCGATTCCTCTGCTGGTGCAGAGTCACAGCGCGCACCAGCTCGTCAC
GCGCTGGTGGGACGGCCGGGACGTGGCACTAAGCGGTCACGCGCTCGCGGAGACGTACTCGGTCCTGACCCGGCTTCCCG
GTGATCTGCGGGTGAGTCCCGCGAATGCGGCCCGCCTGCTACGCGAGCGGTTCGGGCCACCGCTGCTTCTGCGGCCCGGC
ACCGCCGCCCGCCTGCCGGACGTCCTCAGCCGTGCCGACGTGGCGGGCGGCGCGGTCTACGACGCGCTGGTCGCACTGGC
CGCGGCAGAGAATGGCGCGACCCTGGCTACCCGGGACGCGCGTGCGAAGGGCACGTACGAGGTCGTCGGCGCGCGGGTGA
TCGTGGTCGGTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8277.45 Da        Isoelectric Point: 5.0490

>AT127225 WP_139930834.1 NZ_CP040915:c3969960-3969724 [Georgenia sp. Z443]
MKATVDSVGRIVVPKPLRDALGLREGSTVDISRYGAGLQVVPTGRTARLVEEAGALVVAGETAIDDEDVFRLLDTGRR

Download         Length: 237 bp

>AT127225 NZ_CP040915:c3969960-3969724 [Georgenia sp. Z443]
ATGAAGGCCACCGTGGACTCCGTCGGGCGCATCGTGGTGCCGAAGCCACTTCGTGACGCGCTCGGCCTGCGCGAGGGATC
GACCGTGGACATCTCGCGCTACGGCGCAGGGCTGCAGGTGGTGCCGACCGGGCGCACTGCCCGGCTGGTCGAGGAGGCGG
GGGCGCTCGTCGTGGCGGGCGAGACGGCAATCGACGATGAGGACGTCTTCCGGCTGCTCGACACCGGCCGGAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References