Detailed information of TA system TA127221

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-Xre
• Location: 4618543..4619413
• Replicon: chromosome
• Accession: NZ_CP040914
• Organism: Mesorhizobium sp. 8

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FGU64_RS22305
• Protein ID: WP_139955077.1
• Coordinates: 4618907..4619413 (+)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: FGU64_RS22300
• Protein ID: WP_136359202.1
• Coordinates: 4618543..4618914 (+)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGU64_RS22280	4614040..4615971	+	1932	WP_180375590.1	1-deoxy-D-xylulose-5-phosphate synthase	-
FGU64_RS22285	4616157..4616426	+	270	WP_139955074.1	hypothetical protein	-
FGU64_RS22290	4616468..4617232	+	765	WP_139955075.1	TlyA family RNA methyltransferase	-
FGU64_RS22295	4617229..4618470	+	1242	WP_139955076.1	class I SAM-dependent RNA methyltransferase	-
FGU64_RS22300	4618543..4618914	+	372	WP_136359202.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
FGU64_RS22305	4618907..4619413	+	507	WP_139955077.1	RES domain-containing protein	Toxin
FGU64_RS22310	4619486..4620892	-	1407	WP_139955517.1	metalloprotease TldD	-
FGU64_RS23380	4620998..4621135	+	138	WP_180375591.1	hypothetical protein	-
FGU64_RS22315	4621143..4621688	-	546	WP_139955078.1	invasion associated locus B family protein	-
FGU64_RS22320	4622051..4622914	+	864	WP_139955079.1	cytochrome c oxidase subunit II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (7-161)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-120)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 18824.57 Da
• Isoelectric Point: 7.9701

>T127221 WP_139955077.1 NZ_CP040914:4618907-4619413 [Mesorhizobium sp. 8]
MPDATLTLWRAFVPRWAHLPLSGEGAARFGGRWNPVGAPAIYAARELSTAWAEYNQGFVQHPALIARLELAGANLADLTD
LTVLADLKIRPDIHLCEWRDLMDRGKVPETHRLRRRLLAQGHDGVIYPSHMSPGGSCVALWRWNDKDAPRLDVIDPDHRL
PKTAASWL

Nucleotide

• Length: 507 bp

>T127221 NZ_CP040914:4618907-4619413 [Mesorhizobium sp. 8]
ATGCCTGATGCGACGCTGACGCTGTGGCGCGCCTTCGTGCCGCGCTGGGCGCATCTGCCGCTGTCGGGCGAGGGGGCCGC
CCGCTTCGGCGGCCGCTGGAACCCGGTCGGCGCGCCGGCCATCTATGCCGCGCGCGAGCTTTCGACCGCCTGGGCCGAAT
ACAATCAGGGTTTCGTCCAGCATCCGGCGCTCATCGCGCGGCTGGAACTCGCCGGTGCCAATCTGGCGGATCTGACGGAC
CTGACCGTTCTTGCCGACCTGAAGATCAGACCGGACATTCACCTCTGCGAATGGCGCGACCTGATGGATCGCGGCAAGGT
GCCGGAAACGCACCGGCTGCGGCGCAGGCTTCTTGCGCAAGGCCATGACGGCGTGATCTACCCGTCGCATATGTCGCCTG
GCGGAAGCTGCGTGGCGCTGTGGCGCTGGAACGACAAGGACGCGCCGAGGCTCGATGTGATCGATCCCGACCACAGGCTG
CCGAAGACTGCGGCGTCGTGGCTATAG

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13157.26 Da
• Isoelectric Point: 10.2721

>AT127221 WP_136359202.1 NZ_CP040914:4618543-4618914 [Mesorhizobium sp. 8]
MTVATFESPALRFGDGRAPFLSARRVAELLGVTLTELAGLIGVARNTLTARTGARKVDAALSPVVRILAMASEMAGSEQR
AAIWFKHQPIPGWAGKTAYDLVREDKADKVLAYLEAVRAGVYA

Nucleotide

• Length: 372 bp

>AT127221 NZ_CP040914:4618543-4618914 [Mesorhizobium sp. 8]
ATGACCGTCGCAACATTCGAGTCTCCCGCCCTGCGCTTCGGCGATGGCCGCGCGCCGTTCCTGTCGGCCCGCCGCGTCGC
CGAACTGCTCGGCGTCACGCTGACCGAACTTGCCGGGCTGATCGGCGTCGCCCGCAACACGCTGACGGCGCGCACCGGCG
CCCGCAAGGTCGACGCCGCCTTGAGCCCCGTCGTGCGCATCCTGGCGATGGCCAGCGAAATGGCGGGCAGCGAGCAGCGC
GCCGCCATCTGGTTCAAGCACCAGCCGATACCCGGCTGGGCCGGCAAGACCGCCTACGATCTCGTGCGGGAGGACAAGGC
CGACAAGGTGCTCGCCTATCTGGAGGCCGTGCGCGCCGGCGTCTATGCCTGA