Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2861364..2861970 Replicon chromosome
Accession NZ_CP040914
Organism Mesorhizobium sp. 8

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FGU64_RS13960 Protein ID WP_139953762.1
Coordinates 2861782..2861970 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FGU64_RS13955 Protein ID WP_139953761.1
Coordinates 2861364..2861780 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU64_RS13925 2856510..2857145 - 636 WP_139953756.1 class I SAM-dependent methyltransferase -
FGU64_RS13930 2857165..2857986 - 822 WP_139953757.1 amino acid ABC transporter permease -
FGU64_RS13935 2858046..2858846 - 801 WP_139953758.1 transporter substrate-binding domain-containing protein -
FGU64_RS13940 2859044..2859568 - 525 WP_139953759.1 50S ribosomal protein L19 -
FGU64_RS13945 2859910..2860659 + 750 WP_139953760.1 sulfite exporter TauE/SafE family protein -
FGU64_RS13950 2860652..2861353 - 702 WP_139955388.1 tRNA (guanosine(37)-N1)-methyltransferase TrmD -
FGU64_RS13955 2861364..2861780 - 417 WP_139953761.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FGU64_RS13960 2861782..2861970 - 189 WP_139953762.1 type II toxin-antitoxin system HicA family toxin Toxin
FGU64_RS13965 2862009..2862629 - 621 WP_139953763.1 ribosome maturation factor RimM -
FGU64_RS13970 2862697..2863635 + 939 WP_139953764.1 tyrosine recombinase XerC -
FGU64_RS13975 2864102..2864395 + 294 WP_210239078.1 dynamin -
FGU64_RS13980 2864467..2865870 - 1404 WP_139953766.1 dihydrolipoyl dehydrogenase -
FGU64_RS13985 2865952..2866425 - 474 WP_139953767.1 hypothetical protein -
FGU64_RS13990 2866461..2866862 - 402 WP_139953768.1 MAPEG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7060.17 Da        Isoelectric Point: 11.9780

>T127220 WP_139953762.1 NZ_CP040914:c2861970-2861782 [Mesorhizobium sp. 8]
MRSRDVIRRLEADGWREVARKGSHAQFKHPTKAGRVTVPDPRRDIPIGTLRSIEKQSGVKLV

Download         Length: 189 bp

>T127220 NZ_CP040914:c2861970-2861782 [Mesorhizobium sp. 8]
ATGCGTAGCCGTGACGTCATCAGGCGACTTGAGGCTGACGGATGGCGGGAGGTGGCGCGCAAGGGAAGTCATGCGCAGTT
CAAGCATCCGACCAAGGCGGGGCGGGTTACGGTTCCCGATCCGCGACGGGATATTCCCATCGGCACCTTGCGCAGCATCG
AGAAGCAATCGGGTGTGAAGCTGGTCTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15071.79 Da        Isoelectric Point: 4.3436

>AT127220 WP_139953761.1 NZ_CP040914:c2861780-2861364 [Mesorhizobium sp. 8]
MANYIGLIHKDIDSDYGVSFPDFPGCVSAGPTLDDARAGAEEALALHIEGMIEDGDSIPEPSSLEAVMADPDNRDGVAIL
VKVPDADQRSIRVNVTFPEDVLRQIDLFAQDTGYTRSGFLARAAKHEIERETRRKTRA

Download         Length: 417 bp

>AT127220 NZ_CP040914:c2861780-2861364 [Mesorhizobium sp. 8]
ATGGCAAATTACATCGGTCTCATCCACAAGGACATCGACAGCGACTACGGTGTCTCCTTTCCTGATTTTCCGGGATGCGT
TTCAGCGGGTCCGACGCTCGACGATGCCCGTGCCGGCGCGGAGGAGGCATTGGCATTGCACATCGAGGGTATGATCGAGG
ACGGGGATTCTATCCCCGAGCCGTCCTCCCTTGAGGCCGTCATGGCCGACCCCGACAACCGTGACGGCGTCGCCATACTG
GTAAAGGTGCCCGATGCGGACCAGCGTTCCATCCGCGTCAACGTGACCTTTCCCGAGGATGTGTTGAGGCAGATCGATCT
GTTTGCACAAGACACGGGCTACACGCGGTCCGGCTTCCTTGCTCGCGCTGCAAAGCACGAGATCGAGCGTGAGACGCGGC
GCAAGACACGCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References