Detailed information of TA system TA127219

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RHH(antitoxin)
• Location: 2833302..2833855
• Replicon: chromosome
• Accession: NZ_CP040914
• Organism: Mesorhizobium sp. 8

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FGU64_RS13835
• Protein ID: WP_136356597.1
• Coordinates: 2833562..2833855 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FGU64_RS13830
• Protein ID: WP_136356599.1
• Coordinates: 2833302..2833574 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGU64_RS13800	2828424..2828711	-	288	WP_139953737.1	hypothetical protein	-
FGU64_RS13805	2828966..2830792	+	1827	WP_139953738.1	translational GTPase TypA	-
FGU64_RS13810	2830813..2831223	-	411	WP_136356607.1	type II toxin-antitoxin system VapC family toxin	-
FGU64_RS13815	2831220..2831462	-	243	WP_180375531.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
FGU64_RS13820	2831536..2832567	+	1032	WP_139953740.1	DMT family transporter	-
FGU64_RS13825	2832629..2833243	+	615	WP_139953741.1	LysE family translocator	-
FGU64_RS13830	2833302..2833574	+	273	WP_136356599.1	CopG family ribbon-helix-helix protein	Antitoxin
FGU64_RS13835	2833562..2833855	+	294	WP_136356597.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FGU64_RS13840	2833859..2834422	-	564	WP_139953742.1	peroxidase-related enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10957.48 Da
• Isoelectric Point: 6.7192

>T127219 WP_136356597.1 NZ_CP040914:2833562-2833855 [Mesorhizobium sp. 8]
VPRVIVTAGAAAGLERCRRFLVDKNPFAARRAAETVGRHFSFLETHPEIGRPEPDEPQLRELLIPFGDSGYVALYRFIAE
EDSVFILAFRHQKEAGY

Nucleotide

• Length: 294 bp

>T127219 NZ_CP040914:2833562-2833855 [Mesorhizobium sp. 8]
GTGCCACGAGTGATCGTGACTGCCGGCGCAGCGGCCGGCCTTGAACGGTGCAGACGCTTTCTGGTCGATAAGAATCCTTT
CGCCGCAAGGCGCGCCGCCGAGACCGTAGGCAGGCATTTTTCGTTCCTCGAAACACATCCCGAAATCGGGCGTCCGGAGC
CTGACGAACCGCAATTGCGTGAACTGCTCATCCCGTTCGGGGATTCCGGCTACGTCGCACTCTATCGCTTCATTGCCGAG
GAAGATTCCGTCTTCATACTCGCGTTCAGACACCAGAAAGAAGCGGGCTACTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10606.70 Da
• Isoelectric Point: 4.7901

>AT127219 WP_136356599.1 NZ_CP040914:2833302-2833574 [Mesorhizobium sp. 8]
MAISVKIDDDLKSRVQRLAESRRRSSHWIMREAIEQYVEREEARASFRAEAQESWVAYRETGLHLTGQEVRDWLGSWGTE
EETEVPTCHE

Nucleotide

• Length: 273 bp

>AT127219 NZ_CP040914:2833302-2833574 [Mesorhizobium sp. 8]
ATGGCCATTTCAGTCAAGATCGACGACGACCTGAAAAGCCGCGTGCAACGACTGGCGGAGAGCCGCCGGCGTTCGTCGCA
TTGGATCATGCGCGAAGCAATCGAACAGTATGTCGAGCGCGAGGAGGCGCGTGCAAGCTTTCGCGCCGAGGCGCAAGAGT
CATGGGTCGCCTATCGTGAAACAGGGCTGCACCTGACGGGACAGGAAGTGCGTGACTGGCTAGGCAGCTGGGGCACCGAA
GAGGAAACGGAAGTCCCCACGTGCCACGAGTGA