Detailed information of TA system TA127212

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 474454..475107
• Replicon: chromosome
• Accession: NZ_CP040911
• Organism: Acinetobacter pittii strain AB17H194

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: E8E07_RS02335
• Protein ID: WP_086399324.1
• Coordinates: 474718..475107 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A009HHW9
• Locus tag: E8E07_RS02330
• Protein ID: WP_002117064.1
• Coordinates: 474454..474711 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E8E07_RS02310	469967..470974	+	1008	WP_002116730.1	DNA-directed RNA polymerase subunit alpha	-
E8E07_RS02315	470993..471370	+	378	WP_002049717.1	50S ribosomal protein L17	-
E8E07_RS02320	471552..473042	+	1491	WP_002116796.1	NAD(P)/FAD-dependent oxidoreductase	-
E8E07_RS02325	473093..474265	-	1173	WP_017386981.1	acyl-CoA dehydrogenase family protein	-
E8E07_RS02330	474454..474711	+	258	WP_002117064.1	succinate dehydrogenase assembly factor 2	Antitoxin
E8E07_RS02335	474718..475107	+	390	WP_086399324.1	hypothetical protein	Toxin
E8E07_RS02340	475878..476966	+	1089	WP_014207738.1	hypothetical protein	-
E8E07_RS02345	477051..477626	+	576	WP_140157903.1	rhombosortase	-
E8E07_RS02350	477806..480001	+	2196	WP_017400431.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15586.65 Da
• Isoelectric Point: 6.3102

>T127212 WP_086399324.1 NZ_CP040911:474718-475107 [Acinetobacter pittii]
MIKELNFELKYSRVSVVFQLFVGLGLAILLYQLLTPMWWLCAVILLFIGFIFFLKQVQISQIEYLDQKLWSVAYFSEKEI
YRAEITKIIDYQLFVVIYFEETPTNIAIVWFDQLPIQQWKRLKVLEKLY

Nucleotide

• Length: 390 bp

>T127212 NZ_CP040911:474718-475107 [Acinetobacter pittii]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGTCGTGTCTCGGTAGTATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATTCTGCTTTATCAATTATTAACACCCATGTGGTGGCTATGCGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTT
TAAAGCAAGTACAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTGCATATTTCTCGGAAAAAGAAATT
TACCGTGCAGAAATTACTAAAATAATTGATTATCAGCTATTTGTAGTTATTTATTTTGAAGAGACTCCTACGAATATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10295.73 Da
• Isoelectric Point: 4.4809

>AT127212 WP_002117064.1 NZ_CP040911:474454-474711 [Acinetobacter pittii]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Nucleotide

• Length: 258 bp

>AT127212 NZ_CP040911:474454-474711 [Acinetobacter pittii]
ATGTCTGACGAAATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGCGGCTTAAAAGAAATTGACGTCTATTT
TGACCCGTATGTAAAAAACTATTATTTAAAAGCTGATCCGGCAGAAAAAGCATTATTTGCAGAGTTAGTCGATCAAGAAG
ATCCAGATTTATTAGATTGGTTCATGGAAGTTTCTGAACCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAA
CAGTATGTGCATGGCTAA

Structures

Antitoxin

• AlphaFold DB: A0A009HHW9