Detailed information of TA system TA127204

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 14494..15019
• Replicon: plasmid pCFSAN074387
• Accession: NZ_CP040901
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain SAP18-6199

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: FF984_RS23735
• Protein ID: WP_001159863.1
• Coordinates: 14714..15019 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: FF984_RS23730
• Protein ID: WP_000813641.1
• Coordinates: 14494..14712 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF984_RS23700	9781..10162	+	382	Protein_11	YgiW/YdeI family stress tolerance OB fold protein	-
FF984_RS23705	10331..10775	+	445	Protein_12	site-specific integrase	-
FF984_RS23710	11034..12023	-	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
FF984_RS23715	12517..12813	-	297	WP_001687482.1	hypothetical protein	-
FF984_RS23725	13297..13818	-	522	WP_010999942.1	hypothetical protein	-
FF984_RS23730	14494..14712	+	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
FF984_RS23735	14714..15019	+	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
FF984_RS23740	15021..15311	+	291	WP_001266176.1	hypothetical protein	-
FF984_RS23745	15308..15829	+	522	WP_000198608.1	hypothetical protein	-
FF984_RS23750	15864..16646	+	783	WP_000082169.1	site-specific integrase	-
FF984_RS23755	16655..17368	+	714	Protein_21	EAL domain-containing protein	-
FF984_RS23765	17372..17881	+	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
FF984_RS23770	17875..18360	+	486	WP_000905606.1	membrane protein	-
FF984_RS23775	18637..18924	-	288	WP_071530243.1	hypothetical protein	-
FF984_RS23780	19080..19640	+	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93930	93930

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 13091.77 Da
• Isoelectric Point: 12.8043

>T127204 WP_001159863.1 NZ_CP040901:14714-15019 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 306 bp

>T127204 NZ_CP040901:14714-15019 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 12.6573

>AT127204 WP_000813641.1 NZ_CP040901:14494-14712 [Salmonella enterica subsp. enterica serovar Typhimurium]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 219 bp

>AT127204 NZ_CP040901:14494-14712 [Salmonella enterica subsp. enterica serovar Typhimurium]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6