Detailed information of TA system TA127200

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): omega-epsilon-zeta/zeta-epsilon
• Location: 1433032..1434169
• Replicon: chromosome
• Accession: NZ_CP040898
• Organism: Enterococcus faecalis strain HA-1

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: -
• Locus tag: FHO10_RS07585
• Protein ID: WP_002401483.1
• Coordinates: 1433306..1434169 (+)
• Length: 288 a.a.

Antitoxin (Protein)

• Gene name: epsilon
• Uniprot ID: R2XCR7
• Locus tag: FHO10_RS07580
• Protein ID: WP_000301765.1
• Coordinates: 1433032..1433304 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FHO10_RS07540	1428228..1429905	+	1678	Protein_1310	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
FHO10_RS07545	1430039..1430278	+	240	WP_000635249.1	peptide-binding protein	-
FHO10_RS07550	1430327..1430410	+	84	WP_001814874.1	23S rRNA methyltransferase attenuation leader peptide	-
FHO10_RS07555	1430535..1431272	+	738	WP_002292226.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B)	-
FHO10_RS07565	1431418..1431702	+	285	WP_073459356.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
FHO10_RS07570	1431805..1432701	+	897	WP_002387620.1	ParA family protein	-
FHO10_RS07575	1432806..1433015	+	210	WP_000527317.1	peptide-binding protein	-
FHO10_RS07580	1433032..1433304	+	273	WP_000301765.1	antitoxin	Antitoxin
FHO10_RS07585	1433306..1434169	+	864	WP_002401483.1	zeta toxin family protein	Toxin
FHO10_RS07590	1434610..1434927	+	318	WP_002333463.1	hypothetical protein	-
FHO10_RS07595	1434947..1435234	+	288	Protein_1320	DnaJ domain-containing protein	-
FHO10_RS07600	1435308..1435988	+	681	WP_010710189.1	IS6-like element IS1216 family transposase	-
FHO10_RS07605	1436044..1436475	+	432	Protein_1322	2-dehydropantoate 2-reductase	-
FHO10_RS07610	1436751..1437602	+	852	WP_002357480.1	ribosome biogenesis GTPase YlqF	-
FHO10_RS07615	1437604..1438371	+	768	WP_002357481.1	ribonuclease HII	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	erm(B)	-	1426663..1435988	9325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (27-213)

Antitoxin

• Bacterial epsilon antitoxin (2-90)

Sequences

Toxin

Protein

• Length: 288 a.a.
• Molecular weight: 32486.06 Da
• Isoelectric Point: 6.9965

>T127200 WP_002401483.1 NZ_CP040898:1433306-1434169 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Nucleotide

• Length: 864 bp

>T127200 NZ_CP040898:1433306-1434169 [Enterococcus faecalis]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTCACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGCTATAATTTAGTGATTGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTTATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GATTAGAAACGCCTTCTATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGCTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10721.25 Da
• Isoelectric Point: 6.4676

>AT127200 WP_000301765.1 NZ_CP040898:1433032-1433304 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Nucleotide

• Length: 273 bp

>AT127200 NZ_CP040898:1433032-1433304 [Enterococcus faecalis]
ATGGCAGTTACATATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A829F0A3