Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3285738..3286302 Replicon chromosome
Accession NZ_CP040887
Organism Serinicoccus chungangensis strain CCUG 59777

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FHD63_RS14985 Protein ID WP_139722740.1
Coordinates 3285738..3286085 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FHD63_RS14990 Protein ID WP_139722741.1
Coordinates 3286072..3286302 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHD63_RS14960 3281296..3281874 + 579 WP_139722737.1 TetR/AcrR family transcriptional regulator -
FHD63_RS14965 3281871..3282857 + 987 WP_139722738.1 DMT family transporter -
FHD63_RS14970 3282824..3283515 + 692 Protein_2942 HAD-IA family hydrolase -
FHD63_RS14975 3283854..3285065 + 1212 WP_139722739.1 IS110 family transposase -
FHD63_RS14980 3285222..3285632 - 411 WP_134774227.1 GNAT family N-acetyltransferase -
FHD63_RS14985 3285738..3286085 - 348 WP_139722740.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FHD63_RS14990 3286072..3286302 - 231 WP_139722741.1 ribbon-helix-helix domain-containing protein Antitoxin
FHD63_RS14995 3286396..3287073 - 678 WP_139722742.1 hypothetical protein -
FHD63_RS15000 3287325..3287840 + 516 WP_139722743.1 hypothetical protein -
FHD63_RS15005 3288007..3288810 + 804 WP_139722744.1 hypothetical protein -
FHD63_RS15010 3288943..3289230 + 288 WP_139722745.1 hypothetical protein -
FHD63_RS15015 3289622..3290143 + 522 WP_158296813.1 CPBP family intramembrane metalloprotease -
FHD63_RS15020 3290233..3290457 - 225 WP_139722747.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3281871..3290457 8586


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12540.59 Da        Isoelectric Point: 11.1582

>T127188 WP_139722740.1 NZ_CP040887:c3286085-3285738 [Serinicoccus chungangensis]
MLRGEILLVDLDPVRGSEANKRRPAVLVSNDRANTMAQRLGRGVVTVLPVTSNVERVFPFQVLLPADETGLRVDSKAQAE
QVRSVAVERVGPAVGRVPPRLMAAVDEALRIHLQL

Download         Length: 348 bp

>T127188 NZ_CP040887:c3286085-3285738 [Serinicoccus chungangensis]
ATGCTGCGCGGTGAGATCCTTCTCGTCGATCTGGATCCAGTTCGCGGTAGCGAGGCCAACAAGCGGCGTCCCGCGGTGCT
TGTCAGCAATGACCGGGCGAACACCATGGCTCAACGACTCGGTCGTGGAGTCGTCACCGTCCTGCCCGTGACCAGCAACG
TGGAGCGGGTCTTCCCGTTCCAGGTGTTGCTGCCAGCTGACGAGACAGGACTGCGGGTGGACTCCAAGGCCCAGGCGGAG
CAGGTGCGCTCGGTCGCAGTCGAAAGGGTCGGGCCTGCAGTAGGCCGGGTGCCGCCCCGCCTCATGGCTGCGGTCGACGA
AGCGTTGCGAATCCATCTCCAACTATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8197.91 Da        Isoelectric Point: 3.8308

>AT127188 WP_139722741.1 NZ_CP040887:c3286302-3286072 [Serinicoccus chungangensis]
MKVSVSLSEEDLAALDRYVEEAGLESRSAAVQQAIRRLQDPQLEAAYAAAWEEWAVVGDEDAWASASSDGLTDAAR

Download         Length: 231 bp

>AT127188 NZ_CP040887:c3286302-3286072 [Serinicoccus chungangensis]
ATGAAGGTGAGCGTGAGTCTGAGCGAGGAAGACCTCGCGGCCCTCGACCGATACGTCGAAGAAGCTGGCCTCGAGTCGAG
GTCCGCTGCCGTCCAGCAGGCCATCCGCCGCCTACAAGACCCGCAGCTGGAGGCGGCCTATGCCGCCGCCTGGGAGGAGT
GGGCCGTCGTTGGGGACGAGGACGCCTGGGCATCAGCGTCCTCGGACGGGCTAACCGATGCTGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References