Detailed information of TA system TA127188

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 3285738..3286302
• Replicon: chromosome
• Accession: NZ_CP040887
• Organism: Serinicoccus chungangensis strain CCUG 59777

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FHD63_RS14985
• Protein ID: WP_139722740.1
• Coordinates: 3285738..3286085 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: FHD63_RS14990
• Protein ID: WP_139722741.1
• Coordinates: 3286072..3286302 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FHD63_RS14960	3281296..3281874	+	579	WP_139722737.1	TetR/AcrR family transcriptional regulator	-
FHD63_RS14965	3281871..3282857	+	987	WP_139722738.1	DMT family transporter	-
FHD63_RS14970	3282824..3283515	+	692	Protein_2942	HAD-IA family hydrolase	-
FHD63_RS14975	3283854..3285065	+	1212	WP_139722739.1	IS110 family transposase	-
FHD63_RS14980	3285222..3285632	-	411	WP_134774227.1	GNAT family N-acetyltransferase	-
FHD63_RS14985	3285738..3286085	-	348	WP_139722740.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FHD63_RS14990	3286072..3286302	-	231	WP_139722741.1	ribbon-helix-helix domain-containing protein	Antitoxin
FHD63_RS14995	3286396..3287073	-	678	WP_139722742.1	hypothetical protein	-
FHD63_RS15000	3287325..3287840	+	516	WP_139722743.1	hypothetical protein	-
FHD63_RS15005	3288007..3288810	+	804	WP_139722744.1	hypothetical protein	-
FHD63_RS15010	3288943..3289230	+	288	WP_139722745.1	hypothetical protein	-
FHD63_RS15015	3289622..3290143	+	522	WP_158296813.1	CPBP family intramembrane metalloprotease	-
FHD63_RS15020	3290233..3290457	-	225	WP_139722747.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3281871..3290457	8586

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-113)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-38)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12540.59 Da
• Isoelectric Point: 11.1582

>T127188 WP_139722740.1 NZ_CP040887:c3286085-3285738 [Serinicoccus chungangensis]
MLRGEILLVDLDPVRGSEANKRRPAVLVSNDRANTMAQRLGRGVVTVLPVTSNVERVFPFQVLLPADETGLRVDSKAQAE
QVRSVAVERVGPAVGRVPPRLMAAVDEALRIHLQL

Nucleotide

• Length: 348 bp

>T127188 NZ_CP040887:c3286085-3285738 [Serinicoccus chungangensis]
ATGCTGCGCGGTGAGATCCTTCTCGTCGATCTGGATCCAGTTCGCGGTAGCGAGGCCAACAAGCGGCGTCCCGCGGTGCT
TGTCAGCAATGACCGGGCGAACACCATGGCTCAACGACTCGGTCGTGGAGTCGTCACCGTCCTGCCCGTGACCAGCAACG
TGGAGCGGGTCTTCCCGTTCCAGGTGTTGCTGCCAGCTGACGAGACAGGACTGCGGGTGGACTCCAAGGCCCAGGCGGAG
CAGGTGCGCTCGGTCGCAGTCGAAAGGGTCGGGCCTGCAGTAGGCCGGGTGCCGCCCCGCCTCATGGCTGCGGTCGACGA
AGCGTTGCGAATCCATCTCCAACTATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8197.91 Da
• Isoelectric Point: 3.8308

>AT127188 WP_139722741.1 NZ_CP040887:c3286302-3286072 [Serinicoccus chungangensis]
MKVSVSLSEEDLAALDRYVEEAGLESRSAAVQQAIRRLQDPQLEAAYAAAWEEWAVVGDEDAWASASSDGLTDAAR

Nucleotide

• Length: 231 bp

>AT127188 NZ_CP040887:c3286302-3286072 [Serinicoccus chungangensis]
ATGAAGGTGAGCGTGAGTCTGAGCGAGGAAGACCTCGCGGCCCTCGACCGATACGTCGAAGAAGCTGGCCTCGAGTCGAG
GTCCGCTGCCGTCCAGCAGGCCATCCGCCGCCTACAAGACCCGCAGCTGGAGGCGGCCTATGCCGCCGCCTGGGAGGAGT
GGGCCGTCGTTGGGGACGAGGACGCCTGGGCATCAGCGTCCTCGGACGGGCTAACCGATGCTGCGCGGTGA