Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 1877482..1878526 Replicon chromosome
Accession NZ_CP040886
Organism Escherichia coli strain K71-77

Toxin (Protein)


Gene name panT Uniprot ID A0A829CP20
Locus tag FHY70_RS11075 Protein ID WP_000019186.1
Coordinates 1877482..1878030 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag FHY70_RS11080 Protein ID WP_000287252.1
Coordinates 1878053..1878526 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHY70_RS11030 1872694..1873245 - 552 WP_000515860.1 hypothetical protein -
FHY70_RS11035 1873289..1873489 - 201 WP_000649477.1 helix-turn-helix domain-containing protein -
FHY70_RS11040 1873580..1874254 + 675 WP_000859462.1 LexA family transcriptional repressor -
FHY70_RS11055 1874921..1875283 + 363 WP_000135682.1 hypothetical protein -
FHY70_RS11060 1875349..1876173 + 825 WP_001753751.1 DUF2303 family protein -
FHY70_RS11065 1876390..1877142 + 753 WP_001701368.1 hypothetical protein -
FHY70_RS11070 1877179..1877448 + 270 WP_001093912.1 pyocin activator PrtN family protein -
FHY70_RS11075 1877482..1878030 - 549 WP_000019186.1 hypothetical protein Toxin
FHY70_RS11080 1878053..1878526 - 474 WP_000287252.1 SocA family protein Antitoxin
FHY70_RS11085 1878813..1878935 - 123 WP_001300034.1 hypothetical protein -
FHY70_RS11090 1879298..1880314 - 1017 WP_000912595.1 DUF2713 family protein -
FHY70_RS11100 1880632..1881147 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
FHY70_RS11105 1881189..1881398 - 210 WP_001030593.1 CsbD family protein -
FHY70_RS11110 1881514..1882839 - 1326 WP_001301116.1 MATE family efflux transporter DinF -
FHY70_RS11115 1882912..1883520 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1854332..1883998 29666


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20026.39 Da        Isoelectric Point: 4.4481

>T127169 WP_000019186.1 NZ_CP040886:c1878030-1877482 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKAPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

>T127169 NZ_CP040886:c1878030-1877482 [Escherichia coli]
ATGTCTCATAATTCAGATATCTATAAACTGATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAGCAGGCTTTTGAATCCGCATTTGAGCCGTCTAATCATGAACGCGATGATGATTCTTCTTCAG
AAAATAAGGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTCCGGACAAAAATGGCATCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGGCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT127169 WP_000287252.1 NZ_CP040886:c1878526-1878053 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT127169 NZ_CP040886:c1878526-1878053 [Escherichia coli]
ATGTACAGTCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGACTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATCGTTACTATGGATCCGCAAGCAGAGAGCATTATCGGGGCTGTTTATAAGTTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCGA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CP20

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References