Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 829460..829989 Replicon chromosome
Accession NZ_CP040883
Organism Staphylococcus epidermidis strain O47

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag FHQ17_RS03845 Protein ID WP_001829891.1
Coordinates 829627..829989 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag FHQ17_RS03840 Protein ID WP_001829931.1
Coordinates 829460..829630 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHQ17_RS03815 825285..825764 + 480 WP_001829909.1 PH domain-containing protein -
FHQ17_RS03820 825757..827262 + 1506 WP_001829976.1 PH domain-containing protein -
FHQ17_RS03825 827249..827758 + 510 WP_001829888.1 PH domain-containing protein -
FHQ17_RS03830 827806..828159 + 354 WP_001829915.1 holo-ACP synthase -
FHQ17_RS03835 828225..829373 + 1149 WP_002468951.1 alanine racemase -
FHQ17_RS03840 829460..829630 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
FHQ17_RS03845 829627..829989 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FHQ17_RS03850 830335..831336 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
FHQ17_RS03855 831436..831762 + 327 WP_001829952.1 anti-sigma factor antagonist -
FHQ17_RS03860 831764..832243 + 480 WP_001829903.1 anti-sigma B factor RsbW -
FHQ17_RS03865 832218..832988 + 771 WP_002468952.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T127153 WP_001829891.1 NZ_CP040883:829627-829989 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T127153 NZ_CP040883:829627-829989 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT127153 WP_001829931.1 NZ_CP040883:829460-829630 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT127153 NZ_CP040883:829460-829630 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTTCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References