Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsdAT/- |
Location | 818277..818786 | Replicon | chromosome |
Accession | NZ_CP040883 | ||
Organism | Staphylococcus epidermidis strain O47 |
Toxin (Protein)
Gene name | TsdT | Uniprot ID | Q5HMD5 |
Locus tag | FHQ17_RS03785 | Protein ID | WP_001829980.1 |
Coordinates | 818577..818786 (+) | Length | 70 a.a. |
Antitoxin (Protein)
Gene name | TsdA | Uniprot ID | Q5HMD4 |
Locus tag | FHQ17_RS03780 | Protein ID | WP_001829893.1 |
Coordinates | 818277..818570 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FHQ17_RS03755 | 813285..814073 | + | 789 | WP_001829971.1 | hydroxyethylthiazole kinase | - |
FHQ17_RS03760 | 814079..814717 | + | 639 | WP_002505076.1 | thiamine phosphate synthase | - |
FHQ17_RS03765 | 814806..815678 | + | 873 | WP_002458703.1 | membrane protein insertase YidC | - |
FHQ17_RS03770 | 815784..816437 | - | 654 | WP_001829983.1 | HD domain-containing protein | - |
FHQ17_RS03775 | 816619..818103 | - | 1485 | WP_174168250.1 | cardiolipin synthase | - |
FHQ17_RS03780 | 818277..818570 | + | 294 | WP_001829893.1 | copper-sensing transcriptional repressor CsoR | Antitoxin |
FHQ17_RS03785 | 818577..818786 | + | 210 | WP_001829980.1 | heavy-metal-associated domain-containing protein | Toxin |
FHQ17_RS03790 | 818929..819066 | + | 138 | WP_001829949.1 | hypothetical protein | - |
FHQ17_RS03795 | 819166..820377 | - | 1212 | WP_001829910.1 | rod shape-determining protein RodA | - |
FHQ17_RS03800 | 820768..821841 | + | 1074 | WP_001832735.1 | D-alanine--D-alanine ligase | - |
FHQ17_RS03805 | 821853..823208 | + | 1356 | WP_001832734.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 70 a.a. Molecular weight: 7987.24 Da Isoelectric Point: 7.0080
>T127152 WP_001829980.1 NZ_CP040883:818577-818786 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL
Download Length: 210 bp
>T127152 NZ_CP040883:818577-818786 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11070.65 Da Isoelectric Point: 5.5778
>AT127152 WP_001829893.1 NZ_CP040883:818277-818570 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD
Download Length: 294 bp
>AT127152 NZ_CP040883:818277-818570 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2G7HWU1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0N1EPA7 |