Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 818277..818786 Replicon chromosome
Accession NZ_CP040883
Organism Staphylococcus epidermidis strain O47

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag FHQ17_RS03785 Protein ID WP_001829980.1
Coordinates 818577..818786 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag FHQ17_RS03780 Protein ID WP_001829893.1
Coordinates 818277..818570 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHQ17_RS03755 813285..814073 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
FHQ17_RS03760 814079..814717 + 639 WP_002505076.1 thiamine phosphate synthase -
FHQ17_RS03765 814806..815678 + 873 WP_002458703.1 membrane protein insertase YidC -
FHQ17_RS03770 815784..816437 - 654 WP_001829983.1 HD domain-containing protein -
FHQ17_RS03775 816619..818103 - 1485 WP_174168250.1 cardiolipin synthase -
FHQ17_RS03780 818277..818570 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
FHQ17_RS03785 818577..818786 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
FHQ17_RS03790 818929..819066 + 138 WP_001829949.1 hypothetical protein -
FHQ17_RS03795 819166..820377 - 1212 WP_001829910.1 rod shape-determining protein RodA -
FHQ17_RS03800 820768..821841 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
FHQ17_RS03805 821853..823208 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T127152 WP_001829980.1 NZ_CP040883:818577-818786 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T127152 NZ_CP040883:818577-818786 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT127152 WP_001829893.1 NZ_CP040883:818277-818570 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT127152 NZ_CP040883:818277-818570 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References