Detailed information of TA system TA127151

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2841666..2842342
• Replicon: chromosome
• Accession: NZ_CP040882
• Organism: Sutterella faecalis strain KGMB03119

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FG381_RS11840
• Protein ID: WP_021995405.1
• Coordinates: 2841666..2841863 (+)
• Length: 66 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FG381_RS11845
• Protein ID: WP_139688975.1
• Coordinates: 2841917..2842342 (+)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FG381_RS11810	2836831..2837097	-	267	WP_139688970.1	hypothetical protein	-
FG381_RS11815	2837110..2837340	-	231	WP_139688971.1	hypothetical protein	-
FG381_RS11820	2837478..2837915	-	438	WP_139689220.1	S24 family peptidase	-
FG381_RS11825	2838283..2838546	+	264	WP_139688972.1	helix-turn-helix domain-containing protein	-
FG381_RS11830	2838533..2840776	+	2244	WP_139688973.1	bifunctional DNA primase/polymerase	-
FG381_RS11835	2841108..2841491	+	384	WP_139688974.1	hypothetical protein	-
FG381_RS11840	2841666..2841863	+	198	WP_021995405.1	type II toxin-antitoxin system HicA family toxin	Toxin
FG381_RS11845	2841917..2842342	+	426	WP_139688975.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FG381_RS11850	2842447..2842860	+	414	WP_021995403.1	DUF2513 domain-containing protein	-
FG381_RS11855	2842860..2843327	+	468	WP_139689221.1	HNH endonuclease	-
FG381_RS11860	2843251..2843859	-	609	WP_139688976.1	DUF4145 domain-containing protein	-
FG381_RS11865	2843871..2844140	+	270	WP_139688977.1	hypothetical protein	-
FG381_RS11870	2844173..2844643	+	471	WP_139688978.1	phage terminase small subunit P27 family	-
FG381_RS11875	2844653..2844919	+	267	WP_139688979.1	hypothetical protein	-
FG381_RS11880	2844922..2845338	+	417	WP_139688980.1	hypothetical protein	-
FG381_RS11885	2845411..2847117	+	1707	WP_139688981.1	terminase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2827166..2876054	48888

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 66 a.a.
• Molecular weight: 7641.93 Da
• Isoelectric Point: 11.6169

>T127151 WP_021995405.1 NZ_CP040882:2841666-2841863 [Sutterella faecalis]
MKQSEFLRWLKSMGVEVTHGTRHLRLRAPGSQKTQTMPRHPSAEMNERIRKDIIRDLGLKETTKK

Nucleotide

• Length: 198 bp

>T127151 NZ_CP040882:2841666-2841863 [Sutterella faecalis]
ATGAAGCAAAGTGAATTTCTTCGGTGGCTTAAGTCGATGGGCGTTGAGGTCACCCACGGAACCAGGCACCTTCGCCTGAG
AGCTCCGGGGAGCCAGAAAACGCAAACCATGCCTCGACACCCAAGCGCCGAGATGAACGAAAGAATCCGTAAGGACATCA
TTCGCGATCTCGGCCTCAAGGAAACCACCAAGAAATAA

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15887.23 Da
• Isoelectric Point: 5.0574

>AT127151 WP_139688975.1 NZ_CP040882:2841917-2842342 [Sutterella faecalis]
MSNFDFPCRFEKLEDGTEIVRCRDLPELLSYSVDGEPLENWARYAVEDCVEFRIKDGELIPEASPALPGEYVVRLSANQV
AKILLSNAMARDGVSRAELAKKAELKLPEVTRILDVHHPTKIDRIEATLRSLGHRLQLSIA

Nucleotide

• Length: 426 bp

>AT127151 NZ_CP040882:2841917-2842342 [Sutterella faecalis]
ATGTCAAATTTCGATTTTCCATGCCGCTTTGAAAAGCTTGAGGACGGCACTGAGATTGTTCGTTGCCGGGATCTGCCCGA
ACTTCTGTCATATTCCGTAGATGGCGAGCCTCTTGAAAATTGGGCCCGTTATGCCGTCGAGGATTGTGTCGAGTTCCGTA
TTAAAGATGGAGAACTTATTCCGGAGGCGTCGCCTGCGCTCCCCGGTGAATATGTTGTTCGTCTGAGCGCAAATCAGGTT
GCAAAAATTCTGCTTTCAAATGCGATGGCGCGCGATGGTGTTTCTCGCGCCGAACTCGCTAAGAAGGCCGAACTGAAGCT
TCCTGAAGTGACGCGGATTCTCGACGTTCACCATCCAACGAAGATCGACCGTATTGAGGCCACTCTTCGGTCACTCGGCC
ATAGGCTTCAGCTGTCGATTGCCTAA