127147

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2467201..2467694 Replicon chromosome
Accession NZ_CP040878
Organism Enterococcus faecium strain HB-1

Toxin (Protein)


Gene name relE Uniprot ID A0A133MTG0
Locus tag FHP28_RS13390 Protein ID WP_002329323.1
Coordinates 2467201..2467467 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A829AAJ0
Locus tag FHP28_RS13395 Protein ID WP_002329324.1
Coordinates 2467464..2467694 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHP28_RS13375 2463728..2464291 - 564 WP_002292135.1 nucleotide exchange factor GrpE -
FHP28_RS13380 2464385..2465428 - 1044 WP_016628977.1 heat-inducible transcriptional repressor HrcA -
FHP28_RS13385 2465661..2466827 - 1167 WP_002329321.1 oxygen-independent coproporphyrinogen III oxidase -
FHP28_RS13390 2467201..2467467 - 267 WP_002329323.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FHP28_RS13395 2467464..2467694 - 231 WP_002329324.1 hypothetical protein Antitoxin
FHP28_RS13400 2467896..2468855 + 960 WP_002293280.1 IS30-like element IS6770 family transposase -
FHP28_RS13415 2469238..2469573 - 336 WP_002329326.1 hypothetical protein -
FHP28_RS13420 2469586..2469891 - 306 WP_002329327.1 hypothetical protein -
FHP28_RS13425 2470679..2471269 + 591 WP_002329329.1 glutamine amidotransferase -
FHP28_RS13430 2471479..2471922 - 444 WP_002329330.1 hypothetical protein -
FHP28_RS13435 2471923..2472690 - 768 WP_002329331.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2467896..2468855 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10617.27 Da        Isoelectric Point: 10.1925

>T127147 WP_002329323.1 NZ_CP040878:c2467467-2467201 [Enterococcus faecium]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDDQMVVIAIQV
GHRRNIYD

Download         Length: 267 bp

>T127147 NZ_CP040878:c2467467-2467201 [Enterococcus faecium]
ATGACCTACCGTTTAGAATTCACGCCTGAAATTCAGAAACAACTTCGTAAAATGGACAAGCATCAAGCGACGCTGATTGT
TCGATGGCTGTATCAACATATTGATGGTATTGACGATCCGAGAAAATTCGGAAAAGGATTGACCGCTAATCGTTCAGGAC
AATGGCGTTATCGAATTGGCAAATATCGTGTGTTGGTAGAGATAGAAGATGATCAAATGGTTGTTATCGCTATTCAAGTG
GGACACCGAAGAAATATCTATGATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8863.97 Da        Isoelectric Point: 4.1938

>AT127147 WP_002329324.1 NZ_CP040878:c2467694-2467464 [Enterococcus faecium]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE

Download         Length: 231 bp

>AT127147 NZ_CP040878:c2467694-2467464 [Enterococcus faecium]
ATGGCTATGATTACGGTTCGTGTGAGTGATGCCGAAAAAGAATGGCTTTCTTATATGGCGGAATTTTATGGGATTACTTT
ATCTGAGCTTCTAAAAACCTATTCGATGGAACAACTAGAAGATGAATACGATCGTCAAACGGCTGAAATTGCCCATAAAC
ATTGGGTAGAAAGTGGAAAAACAACAGTATCCATGGAAGAAATCCTTCATGAATTTGGAGGGCTGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133MTG0

Antitoxin

Source ID Structure
AlphaFold DB A0A829AAJ0

References