Detailed information of TA system TA127136

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 814625..815190
• Replicon: chromosome
• Accession: NZ_CP040871
• Organism: Thermomonas sp. SY21

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FHQ07_RS03865
• Protein ID: WP_139715441.1
• Coordinates: 814870..815190 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FHQ07_RS03860
• Protein ID: WP_139715434.1
• Coordinates: 814625..814882 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FHQ07_RS14285	810448..810777	+	330	WP_168191456.1	DUF2007 domain-containing protein	-
FHQ07_RS03825	810900..811229	+	330	WP_139717857.1	hypothetical protein	-
FHQ07_RS03830	811365..811706	+	342	WP_139715428.1	hypothetical protein	-
FHQ07_RS03835	811882..812154	+	273	WP_139715429.1	ribbon-helix-helix protein, CopG family	-
FHQ07_RS03840	812151..812429	+	279	WP_139715430.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FHQ07_RS03845	813193..813615	+	423	WP_139715374.1	hypothetical protein	-
FHQ07_RS03855	814073..814483	+	411	WP_139715432.1	hypothetical protein	-
FHQ07_RS03860	814625..814882	+	258	WP_139715434.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FHQ07_RS03865	814870..815190	+	321	WP_139715441.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FHQ07_RS03870	816945..817328	+	384	WP_139715443.1	hypothetical protein	-
FHQ07_RS03875	817452..817676	+	225	WP_139715445.1	addiction module protein	-
FHQ07_RS03880	817676..817972	+	297	WP_139715446.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FHQ07_RS03885	818069..818422	+	354	WP_139715448.1	low molecular weight protein tyrosine phosphatase family protein	-
FHQ07_RS03890	818516..819055	+	540	WP_139715450.1	DUF2262 domain-containing protein	-
FHQ07_RS03895	819539..819817	+	279	WP_139715452.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FHQ07_RS03900	819817..820110	+	294	WP_139715453.1	HigA family addiction module antidote protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	786898..828678	41780
	-	inside	Integron	-	-	759010..827378	68368

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12193.06 Da
• Isoelectric Point: 8.9191

>T127136 WP_139715441.1 NZ_CP040871:814870-815190 [Thermomonas sp. SY21]
MAEIVWSEPALADLDAIADYIALENSVAASELVKRIFGHIEQLVDHPESGSRPQELGKSRYRQIVEPPCRVFYRYDGHKV
FILHVMRSERLLRMSQLAKRSKQAKT

Nucleotide

• Length: 321 bp

>T127136 NZ_CP040871:814870-815190 [Thermomonas sp. SY21]
ATGGCTGAAATAGTCTGGTCAGAACCCGCCCTCGCGGATCTTGACGCAATCGCCGACTACATTGCACTGGAGAACTCAGT
TGCAGCGTCAGAGCTGGTCAAGCGCATCTTTGGCCACATCGAACAGCTCGTGGATCACCCTGAGAGCGGGAGTCGCCCGC
AAGAGCTTGGGAAATCGCGCTACCGTCAGATCGTGGAGCCGCCTTGCCGCGTGTTCTACCGTTATGACGGGCACAAGGTT
TTTATCCTGCACGTCATGCGGTCGGAACGCCTGCTTCGCATGAGCCAGCTTGCCAAACGTTCCAAGCAGGCAAAGACCTA
A

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9773.36 Da
• Isoelectric Point: 9.7317

>AT127136 WP_139715434.1 NZ_CP040871:814625-814882 [Thermomonas sp. SY21]
MRTELVTTLKRQATELLSDIERDKEPILITQHGLPSAYLLDVETYQLMQQRMTILEGIARGEQALAEGRVATHTQAKKRL
ARWLK

Nucleotide

• Length: 258 bp

>AT127136 NZ_CP040871:814625-814882 [Thermomonas sp. SY21]
ATGCGCACCGAACTCGTCACGACTCTCAAACGGCAGGCCACCGAACTTCTCTCAGATATTGAGCGGGATAAAGAGCCCAT
TCTCATCACCCAGCATGGCCTACCAAGTGCCTACCTCCTGGATGTTGAGACTTACCAGCTCATGCAGCAGCGCATGACCA
TCCTTGAAGGTATTGCCCGTGGGGAGCAAGCGCTGGCTGAGGGCCGGGTGGCAACCCATACACAAGCTAAGAAGCGCCTT
GCCAGATGGCTGAAATAG