Detailed information of TA system TA127134

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 792802..793337
• Replicon: chromosome
• Accession: NZ_CP040871
• Organism: Thermomonas sp. SY21

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FHQ07_RS03705
• Protein ID: WP_139715406.1
• Coordinates: 792802..793101 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: FHQ07_RS03710
• Protein ID: WP_139715407.1
• Coordinates: 793098..793337 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FHQ07_RS03670	788374..788676	+	303	WP_139715400.1	hypothetical protein	-
FHQ07_RS03675	788774..789538	+	765	WP_139715401.1	hypothetical protein	-
FHQ07_RS03680	789735..790160	+	426	WP_139715402.1	hypothetical protein	-
FHQ07_RS03690	790896..791789	+	894	WP_139715404.1	DUF2971 domain-containing protein	-
FHQ07_RS03695	791891..792334	+	444	WP_139715405.1	hypothetical protein	-
FHQ07_RS03700	792421..792723	+	303	WP_139715400.1	hypothetical protein	-
FHQ07_RS03705	792802..793101	-	300	WP_139715406.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FHQ07_RS03710	793098..793337	-	240	WP_139715407.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FHQ07_RS03715	793521..793943	+	423	WP_139715374.1	hypothetical protein	-
FHQ07_RS03720	794066..794404	+	339	WP_139715408.1	hypothetical protein	-
FHQ07_RS03725	794494..795126	+	633	WP_139715409.1	DUF4253 domain-containing protein	-
FHQ07_RS03730	795575..796054	+	480	WP_139715410.1	hypothetical protein	-
FHQ07_RS03735	796210..796497	+	288	WP_139715411.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
FHQ07_RS03740	796499..796753	+	255	WP_139715412.1	helix-turn-helix domain-containing protein	-
FHQ07_RS03745	796844..797059	+	216	WP_139715413.1	hypothetical protein	-
FHQ07_RS03750	797931..798185	+	255	WP_139715414.1	DUF2164 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	786898..828678	41780
	-	inside	Integron	-	-	759010..827378	68368

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (4-71)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11636.34 Da
• Isoelectric Point: 9.4251

>T127134 WP_139715406.1 NZ_CP040871:c793101-792802 [Thermomonas sp. SY21]
MRKFDLTRSAQADLKSIARYTQERWGVRQRNTYLKEVDQVFHALAKNPLMGRACDDIREGYRKFPHGGHVIYYKHLSEDE
LLIVRILHMTMDVDSNISA

Nucleotide

• Length: 300 bp

>T127134 NZ_CP040871:c793101-792802 [Thermomonas sp. SY21]
ATGAGAAAGTTCGATCTCACTAGGTCCGCCCAGGCGGATCTAAAGTCGATCGCGAGATACACGCAGGAGCGCTGGGGTGT
CCGCCAGCGAAATACCTACCTGAAAGAAGTGGATCAGGTGTTCCATGCTCTGGCGAAGAACCCATTGATGGGACGTGCGT
GCGATGACATCCGTGAGGGCTACCGGAAGTTCCCGCATGGCGGGCACGTCATCTATTACAAACATCTGAGTGAAGACGAG
TTGCTGATCGTGCGAATTCTTCACATGACGATGGACGTAGACTCCAACATAAGCGCCTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8665.61 Da
• Isoelectric Point: 5.0790

>AT127134 WP_139715407.1 NZ_CP040871:c793337-793098 [Thermomonas sp. SY21]
MARNTSVSLGDHFEQFIAGQVDSGRYGSASEVVRAGLRLLETTESKLEVLRNALIAGERSGRAKYSYDSLISELDSEQK

Nucleotide

• Length: 240 bp

>AT127134 NZ_CP040871:c793337-793098 [Thermomonas sp. SY21]
ATGGCCAGAAATACCAGTGTCAGCTTGGGTGACCACTTTGAGCAATTCATTGCGGGTCAAGTTGATAGCGGCCGATACGG
CTCTGCTAGCGAGGTCGTGCGGGCGGGCTTGCGTTTGCTTGAGACAACCGAGAGCAAACTCGAAGTTCTGCGAAATGCCC
TGATTGCCGGTGAGCGTAGCGGTCGGGCCAAGTACAGCTATGACTCGCTTATTTCTGAGCTGGACTCTGAGCAGAAATGA