Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 100175..100701 Replicon plasmid unnamed3
Accession NZ_CP040862
Organism Klebsiella pneumoniae strain Xen39

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag FEE38_RS28355 Protein ID WP_000323025.1
Coordinates 100175..100462 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag FEE38_RS28360 Protein ID WP_004196370.1
Coordinates 100462..100701 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEE38_RS28315 95862..96179 - 318 WP_015065519.1 hypothetical protein -
FEE38_RS28320 96194..96544 - 351 WP_163589430.1 hypothetical protein -
FEE38_RS28325 96541..96813 - 273 WP_032425552.1 hypothetical protein -
FEE38_RS28340 97669..98781 - 1113 WP_001300563.1 IS4-like element IS421 family transposase -
FEE38_RS28345 98860..99018 - 159 WP_014343509.1 type I toxin-antitoxin system Hok family toxin -
FEE38_RS28350 99090..100124 + 1035 Protein_108 IS481 family transposase -
FEE38_RS28355 100175..100462 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
FEE38_RS28360 100462..100701 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
FEE38_RS28365 100952..101317 + 366 WP_009651956.1 hypothetical protein -
FEE38_RS28370 101361..102098 + 738 WP_008460272.1 HupE/UreJ family protein -
FEE38_RS28375 102112..102801 + 690 WP_004196322.1 hypothetical protein -
FEE38_RS28380 102832..104208 - 1377 Protein_114 chromate efflux transporter -
FEE38_RS28385 104165..105142 - 978 WP_004196334.1 chromate resistance protein -
FEE38_RS28390 105172..105364 + 193 Protein_116 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - mrkA / mrkB / mrkC / mrkD / mrkF / mrkJ 1..263991 263991


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T127127 WP_000323025.1 NZ_CP040862:c100462-100175 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T127127 NZ_CP040862:c100462-100175 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT127127 WP_004196370.1 NZ_CP040862:c100701-100462 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT127127 NZ_CP040862:c100701-100462 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References