Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2338394..2338910 Replicon chromosome
Accession NZ_CP040861
Organism Klebsiella pneumoniae strain Xen39

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag FEE38_RS12095 Protein ID WP_004178374.1
Coordinates 2338394..2338678 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FEE38_RS12100 Protein ID WP_002886901.1
Coordinates 2338668..2338910 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEE38_RS12070 2333811..2334119 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
FEE38_RS12075 2334204..2334377 + 174 WP_032431440.1 hypothetical protein -
FEE38_RS12080 2334380..2335123 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FEE38_RS12085 2335480..2337618 + 2139 WP_004222153.1 anaerobic ribonucleoside-triphosphate reductase -
FEE38_RS12090 2337926..2338390 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FEE38_RS12095 2338394..2338678 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FEE38_RS12100 2338668..2338910 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FEE38_RS12105 2338988..2340898 - 1911 WP_117096817.1 BglG family transcription antiterminator -
FEE38_RS12110 2340921..2342075 - 1155 WP_002886900.1 lactonase family protein -
FEE38_RS12115 2342142..2342882 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T127113 WP_004178374.1 NZ_CP040861:c2338678-2338394 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T127113 NZ_CP040861:c2338678-2338394 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT127113 WP_002886901.1 NZ_CP040861:c2338910-2338668 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT127113 NZ_CP040861:c2338910-2338668 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References