Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1605585..1606204 Replicon chromosome
Accession NZ_CP040861
Organism Klebsiella pneumoniae strain Xen39

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FEE38_RS08520 Protein ID WP_002892050.1
Coordinates 1605986..1606204 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag FEE38_RS08515 Protein ID WP_002892066.1
Coordinates 1605585..1605959 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEE38_RS08505 1600737..1601930 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FEE38_RS08510 1601953..1605099 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
FEE38_RS08515 1605585..1605959 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
FEE38_RS08520 1605986..1606204 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
FEE38_RS08525 1606363..1606929 + 567 WP_163589157.1 maltose O-acetyltransferase -
FEE38_RS08530 1606901..1607041 - 141 WP_004147370.1 hypothetical protein -
FEE38_RS08535 1607062..1607532 + 471 WP_002892026.1 YlaC family protein -
FEE38_RS08540 1607507..1608958 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
FEE38_RS08545 1609059..1609757 + 699 WP_040220001.1 GNAT family N-acetyltransferase -
FEE38_RS08550 1609754..1609894 - 141 WP_040219999.1 type B 50S ribosomal protein L36 -
FEE38_RS08555 1609894..1610157 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T127111 WP_002892050.1 NZ_CP040861:1605986-1606204 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T127111 NZ_CP040861:1605986-1606204 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAACGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT127111 WP_002892066.1 NZ_CP040861:1605585-1605959 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT127111 NZ_CP040861:1605585-1605959 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References