Detailed information of TA system TA127106

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1926246..1926739
• Replicon: chromosome
• Accession: NZ_CP040852
• Organism: Ligilactobacillus murinus strain V10

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A829DKF8
• Locus tag: FEE40_RS09455
• Protein ID: WP_004047837.1
• Coordinates: 1926464..1926739 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FEE40_RS09450
• Protein ID: WP_135941915.1
• Coordinates: 1926246..1926467 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEE40_RS09425	1921849..1922712	+	864	WP_056960559.1	DegV family protein	-
FEE40_RS09430	1922779..1923612	+	834	WP_163587918.1	sugar phosphate isomerase/epimerase	-
FEE40_RS09435	1923599..1924183	+	585	WP_163587917.1	signal peptidase I	-
FEE40_RS09440	1924287..1925249	+	963	WP_163587921.1	LD-carboxypeptidase	-
FEE40_RS09445	1925521..1925950	-	430	Protein_1820	tyrosine-type recombinase/integrase	-
FEE40_RS09450	1926246..1926467	+	222	WP_135941915.1	translation repressor RelB	Antitoxin
FEE40_RS09455	1926464..1926739	+	276	WP_004047837.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FEE40_RS09460	1927092..1928204	-	1113	WP_004047540.1	IS110 family transposase	-
FEE40_RS09465	1928572..1929399	-	828	Protein_1824	5'-nucleotidase, lipoprotein e(P4) family	-
FEE40_RS09470	1929504..1929797	+	294	WP_004047845.1	hypothetical protein	-
FEE40_RS09475	1929892..1930494	+	603	WP_089135193.1	glycerol-3-phosphate 1-O-acyltransferase PlsY	-
FEE40_RS09480	1930569..1931441	+	873	WP_163588113.1	aldose 1-epimerase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-88)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10984.72 Da
• Isoelectric Point: 10.2588

>T127106 WP_004047837.1 NZ_CP040852:1926464-1926739 [Ligilactobacillus murinus]
MKEYHVEYSKRAQKQIKKLDRQIQRLLFAWIDKNLEGVSDPRIHGKGLTGNHAREWRYRIGDYRLICDIQDDIMIILALE
FGHRRSVYNKK

Nucleotide

• Length: 276 bp

>T127106 NZ_CP040852:1926464-1926739 [Ligilactobacillus murinus]
TTGAAAGAATATCATGTTGAATACTCAAAAAGAGCACAAAAACAAATCAAGAAATTAGATAGACAAATTCAACGGTTGCT
ATTTGCCTGGATAGATAAAAATCTTGAAGGCGTATCTGATCCACGCATACATGGTAAAGGTTTGACTGGAAACCATGCTC
GTGAATGGAGATATAGAATTGGCGACTACCGCCTTATATGTGATATTCAAGATGACATAATGATTATCTTGGCTTTGGAA
TTTGGTCACAGAAGATCTGTGTATAACAAAAAATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8540.55 Da
• Isoelectric Point: 4.3566

>AT127106 WP_135941915.1 NZ_CP040852:1926246-1926467 [Ligilactobacillus murinus]
MATISIRLNQQEEEFFKGYAELTGENLSTLFKEALKKSIDDEYDLQVYKEAYKEYQQDPVTISHADFKKELGL

Nucleotide

• Length: 222 bp

>AT127106 NZ_CP040852:1926246-1926467 [Ligilactobacillus murinus]
ATGGCTACTATTAGTATCAGGCTAAACCAACAAGAAGAAGAATTTTTTAAAGGATATGCAGAACTTACTGGAGAAAACTT
GTCTACTCTCTTCAAAGAAGCTCTTAAAAAAAGCATTGATGATGAATACGATCTTCAGGTATACAAAGAAGCATATAAAG
AGTATCAGCAAGATCCAGTAACTATCTCACATGCTGATTTTAAAAAGGAGTTAGGTCTTTGA

Structures

Toxin

• AlphaFold DB: A0A829DKF8