Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 19949..20468 Replicon plasmid p_unnamned2
Accession NZ_CP040851
Organism Enterococcus faecium strain F17E0263

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag FHK66_RS15045 Protein ID WP_000588503.1
Coordinates 19949..20206 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag FHK66_RS15050 Protein ID WP_000388479.1
Coordinates 20199..20468 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHK66_RS15020 15081..16406 - 1326 WP_139425063.1 Y-family DNA polymerase -
FHK66_RS15025 16856..17461 + 606 WP_002332660.1 recombinase family protein -
FHK66_RS15030 17456..17986 - 531 WP_002332661.1 hypothetical protein -
FHK66_RS15035 17983..19386 - 1404 WP_002332662.1 ATP-binding protein -
FHK66_RS15045 19949..20206 - 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
FHK66_RS15050 20199..20468 - 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FHK66_RS15055 20599..20778 - 180 WP_096573280.1 hypothetical protein -
FHK66_RS15065 21158..21865 - 708 WP_002332739.1 hypothetical protein -
FHK66_RS15070 21858..22295 - 438 WP_010718354.1 hypothetical protein -
FHK66_RS15075 22311..22562 - 252 WP_002343760.1 hypothetical protein -
FHK66_RS15080 22562..22768 - 207 WP_002305810.1 hypothetical protein -
FHK66_RS15085 23213..23473 - 261 WP_002296240.1 hypothetical protein -
FHK66_RS15090 23796..25181 - 1386 WP_139425067.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..63632 63632


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T127105 WP_000588503.1 NZ_CP040851:c20206-19949 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T127105 NZ_CP040851:c20206-19949 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAATTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT127105 WP_000388479.1 NZ_CP040851:c20468-20199 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT127105 NZ_CP040851:c20468-20199 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTATGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References