Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 1775158..1775687 Replicon chromosome
Accession NZ_CP040849
Organism Enterococcus faecium strain F17E0263

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag FHK66_RS09220 Protein ID WP_002294198.1
Coordinates 1775158..1775424 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1S8JTG2
Locus tag FHK66_RS09225 Protein ID WP_002317080.1
Coordinates 1775424..1775687 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHK66_RS09195 1770525..1771700 + 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -
FHK66_RS09200 1771704..1772345 + 642 WP_002293405.1 ABC transporter permease -
FHK66_RS09205 1772342..1773259 + 918 WP_002301114.1 osmoprotectant ABC transporter substrate-binding protein -
FHK66_RS09210 1773256..1773927 + 672 WP_002319469.1 ABC transporter permease -
FHK66_RS09215 1774469..1774957 - 489 WP_002301120.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
FHK66_RS09220 1775158..1775424 - 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
FHK66_RS09225 1775424..1775687 - 264 WP_002317080.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FHK66_RS09235 1776162..1776347 + 186 WP_002294201.1 hypothetical protein -
FHK66_RS09240 1776489..1778312 - 1824 WP_002294202.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T127103 WP_002294198.1 NZ_CP040849:c1775424-1775158 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T127103 NZ_CP040849:c1775424-1775158 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAATCGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCACCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTGGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10015.04 Da        Isoelectric Point: 4.1844

>AT127103 WP_002317080.1 NZ_CP040849:c1775687-1775424 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
NIDWEAL

Download         Length: 264 bp

>AT127103 NZ_CP040849:c1775687-1775424 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACAGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTAGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTGGCTTTACGAATATCGAT
AATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A1S8JTG2

References