Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1367386..1367992 Replicon chromosome
Accession NZ_CP040846
Organism Thermococcus indicus strain IOH1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FH039_RS07540 Protein ID WP_139680818.1
Coordinates 1367594..1367992 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FH039_RS07535 Protein ID WP_139680817.1
Coordinates 1367386..1367607 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH039_RS07515 (FH039_07515) 1362994..1365282 - 2289 WP_139680814.1 alpha-amylase family glycosyl hydrolase -
FH039_RS07520 (FH039_07520) 1365434..1365664 + 231 WP_014011940.1 LSm family protein -
FH039_RS07525 (FH039_07525) 1365690..1365881 + 192 WP_139680815.1 50S ribosomal protein L37e -
FH039_RS07530 (FH039_07530) 1365968..1367338 + 1371 WP_139680816.1 MATE family efflux transporter -
FH039_RS07535 (FH039_07535) 1367386..1367607 + 222 WP_139680817.1 hypothetical protein Antitoxin
FH039_RS07540 (FH039_07540) 1367594..1367992 + 399 WP_139680818.1 type II toxin-antitoxin system VapC family toxin Toxin
FH039_RS07545 (FH039_07545) 1367989..1369083 - 1095 WP_139680819.1 VIT1/CCC1 transporter family protein -
FH039_RS07550 (FH039_07550) 1369216..1370019 + 804 WP_139680820.1 PIG-L deacetylase family protein -
FH039_RS07555 (FH039_07555) 1370012..1370461 - 450 WP_139680821.1 type II toxin-antitoxin system VapC family toxin -
FH039_RS07560 (FH039_07560) 1370464..1370673 - 210 WP_139680822.1 hypothetical protein -
FH039_RS07565 (FH039_07565) 1370670..1372124 - 1455 WP_139680823.1 beta-galactosidase BgaS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(3-129)

Antitoxin

Putative antitoxin VapB3-like

(1-73)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14875.19 Da        Isoelectric Point: 4.9888

>T127100 WP_139680818.1 NZ_CP040846:1367594-1367992 [Thermococcus indicus]
VIVIDASALAKYVLLEPGWERVEELLFKDVVSLDYALAEVSNALWKHHVLYGEISREEFNKRSKVVDALPNVVVLESGMQ
YLEKSRGIAVNHRIPIYDALYIAQALKYGELATSDEKQGEIAKKLGVEVLYL

Download         Length: 399 bp

>T127100 NZ_CP040846:1367594-1367992 [Thermococcus indicus]
GTGATAGTAATTGACGCCTCTGCACTTGCGAAGTACGTTCTCCTCGAACCCGGCTGGGAACGGGTAGAGGAGCTACTTTT
TAAAGACGTCGTCTCACTTGACTATGCCTTGGCAGAGGTTTCAAACGCCCTCTGGAAACATCACGTCCTCTACGGTGAGA
TATCCCGGGAGGAGTTCAATAAGAGATCAAAGGTTGTGGATGCTCTCCCGAACGTCGTCGTTCTTGAGAGTGGAATGCAG
TATTTGGAGAAATCAAGGGGGATAGCTGTTAACCACCGAATCCCAATCTATGACGCCCTCTACATCGCTCAGGCCCTGAA
GTATGGCGAACTTGCCACGAGCGACGAAAAGCAGGGAGAAATAGCGAAAAAACTCGGCGTTGAGGTGCTCTACCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8623.93 Da        Isoelectric Point: 8.5278

>AT127100 WP_139680817.1 NZ_CP040846:1367386-1367607 [Thermococcus indicus]
MAVISVRVPDELKEKMKKYDINWSEEIRRFIALRISKEEKKRTLEMMHELLAGGTPAEEGTAKRYVREDRDSN

Download         Length: 222 bp

>AT127100 NZ_CP040846:1367386-1367607 [Thermococcus indicus]
ATGGCGGTGATAAGCGTCCGCGTTCCGGACGAGCTAAAGGAGAAGATGAAGAAGTACGACATCAACTGGAGCGAGGAGAT
AAGGCGGTTCATAGCCTTGAGGATAAGCAAAGAGGAAAAGAAAAGAACCCTTGAGATGATGCACGAACTGCTTGCCGGAG
GAACCCCCGCCGAGGAAGGGACTGCAAAAAGATACGTGAGGGAGGATCGTGATAGTAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References