Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 1119767..1120383 Replicon chromosome
Accession NZ_CP040846
Organism Thermococcus indicus strain IOH1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FH039_RS06180 Protein ID WP_139680607.1
Coordinates 1119767..1120168 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FH039_RS06185 Protein ID WP_139680608.1
Coordinates 1120156..1120383 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH039_RS06155 (FH039_06155) 1115554..1116771 + 1218 WP_139680605.1 methionine adenosyltransferase -
FH039_RS06160 (FH039_06160) 1116840..1117061 - 222 WP_139681692.1 hypothetical protein -
FH039_RS06165 (FH039_06165) 1117193..1117741 + 549 WP_139681693.1 adenylate kinase family protein -
FH039_RS06170 (FH039_06170) 1117791..1118447 + 657 WP_139680606.1 metallophosphoesterase -
FH039_RS06175 (FH039_06175) 1118451..1119620 - 1170 WP_139681694.1 pyridoxal phosphate-dependent aminotransferase -
FH039_RS06180 (FH039_06180) 1119767..1120168 - 402 WP_139680607.1 PIN domain-containing protein Toxin
FH039_RS06185 (FH039_06185) 1120156..1120383 - 228 WP_139680608.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FH039_RS06190 (FH039_06190) 1120424..1122037 - 1614 WP_139680609.1 carbamoyltransferase -
FH039_RS06195 (FH039_06195) 1122129..1122530 + 402 WP_139680610.1 pyrolysin -
FH039_RS06200 (FH039_06200) 1122597..1124045 - 1449 WP_139681695.1 proline--tRNA ligase -
FH039_RS06205 (FH039_06205) 1124171..1125172 + 1002 WP_139680611.1 2-hydroxyacid dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(5-48)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15342.62 Da        Isoelectric Point: 4.8061

>T127099 WP_139680607.1 NZ_CP040846:c1120168-1119767 [Thermococcus indicus]
MHGVIDTNVLIHDTFEDSEFHSEAEDVLESLDTWYIPAIVLQEFVWFFKNNGFSVDETWEVLKGYLDDPRFRGLNDNPQI
VKKAFEILKVEKLPLSRFNDAMILAHALEKGVLVTFDSKFRKLAGRMGVKVLP

Download         Length: 402 bp

>T127099 NZ_CP040846:c1120168-1119767 [Thermococcus indicus]
ATGCATGGAGTGATAGATACTAACGTCCTCATCCACGACACTTTCGAGGACTCCGAGTTTCACAGCGAGGCAGAAGATGT
CCTGGAGTCCCTCGACACGTGGTATATACCCGCGATAGTCCTCCAAGAGTTCGTCTGGTTCTTCAAGAACAACGGGTTTT
CCGTTGATGAGACGTGGGAAGTTCTGAAGGGCTACCTCGATGACCCGAGGTTCAGGGGGCTCAACGATAATCCACAAATC
GTGAAAAAGGCTTTTGAGATACTGAAGGTTGAGAAACTTCCACTCTCTCGCTTCAACGACGCGATGATTTTAGCCCACGC
CCTTGAGAAGGGCGTTCTGGTAACCTTCGACTCTAAGTTCAGGAAGTTGGCCGGGAGAATGGGCGTTAAAGTTCTTCCGT
AG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8781.41 Da        Isoelectric Point: 10.4649

>AT127099 WP_139680608.1 NZ_CP040846:c1120383-1120156 [Thermococcus indicus]
MSITKVTRNYQITIPAEIRKALGIREGELLEVHLEGDRIVLKRLERKRKRLRLGRKLPPEEIERGIEGGMKECME

Download         Length: 228 bp

>AT127099 NZ_CP040846:c1120383-1120156 [Thermococcus indicus]
ATGAGCATTACCAAAGTAACCCGCAACTATCAGATAACGATTCCGGCGGAGATTAGAAAGGCGCTCGGGATAAGGGAAGG
GGAGCTCCTCGAAGTTCACCTCGAGGGCGACAGGATAGTCCTGAAAAGGCTAGAGCGGAAGAGAAAAAGACTCAGGCTTG
GAAGAAAGCTCCCTCCGGAGGAAATTGAGAGGGGCATCGAGGGGGGCATGAAGGAATGCATGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References