Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 67917..68488 Replicon plasmid pD13
Accession NZ_CP040845
Organism Leptospira weilii strain CUD13

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FHG68_RS21150 Protein ID WP_016758353.1
Coordinates 67917..68258 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828Z2G4
Locus tag FHG68_RS21155 Protein ID WP_004499620.1
Coordinates 68252..68488 (-) Length 79 a.a.

Genomic Context

FHG68_RS21120FHG68_RS21125FHG68_RS21175FHG68_RS21130FHG68_RS21135FHG68_RS21140FHG68_RS21730FHG68_RS21145FHG68_RS21150FHG68_RS21155FHG68_RS21160FHG68_RS21165FHG68_RS21180FHG68_RS21185FHG68_RS21190FHG68_RS21200
Location: 64579..65019 (441 bp)
Type: Others
Protein ID: WP_004497511.1
Location: 65075..65578 (504 bp)
Type: Others
Protein ID: WP_080634873.1
Location: 70389..70523 (135 bp)
Type: Others
Protein ID: WP_085988574.1
Location: 65701..66102 (402 bp)
Type: Others
Protein ID: WP_004500217.1
Location: 66104..66391 (288 bp)
Type: Others
Protein ID: WP_026054191.1
Location: 66536..66913 (378 bp)
Type: Others
Protein ID: WP_036075665.1
Location: 67134..67415 (282 bp)
Type: Others
Protein ID: WP_004497523.1
Location: 67658..67873 (216 bp)
Type: Others
Protein ID: WP_004497509.1
Location: 67917..68258 (342 bp)
Type: Toxin
Protein ID: WP_016758353.1
Location: 68252..68488 (237 bp)
Type: Antitoxin
Protein ID: WP_004499620.1
Location: 68828..69217 (390 bp)
Type: Others
Protein ID: WP_036075668.1
Location: 69258..70330 (1073 bp)
Type: Others
Protein ID: Protein_65
Location: 70719..70949 (231 bp)
Type: Others
Protein ID: WP_004497519.1
Location: 71109..71905 (797 bp)
Type: Others
Protein ID: Protein_68
Location: 72072..72275 (204 bp)
Type: Others
Protein ID: WP_004497508.1
Location: 72651..73289 (639 bp)
Type: Others
Protein ID: WP_004499330.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FHG68_RS2112064579..65019+441WP_004497511.1winged helix-turn-helix domain-containing protein-
FHG68_RS2112565075..65578+504WP_080634873.1IS630 family transposase-
FHG68_RS2113065701..66102-402WP_004500217.1helix-turn-helix domain-containing protein-
FHG68_RS2113566104..66391-288WP_026054191.1type II toxin-antitoxin system HigB family toxin-
FHG68_RS2114066536..66913-378WP_036075665.1hypothetical protein-
FHG68_RS2173067134..67415-282WP_004497523.1hypothetical protein-
FHG68_RS2114567658..67873-216WP_004497509.1hypothetical protein-
FHG68_RS2115067917..68258-342WP_016758353.1endoribonuclease MazFToxin
FHG68_RS2115568252..68488-237WP_004499620.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
FHG68_RS2116068828..69217-390WP_036075668.1hypothetical protein-
FHG68_RS2116569258..70330-1073Protein_65IS3 family transposase-
FHG68_RS2117570389..70523+135WP_085988574.1AraC family transcriptional regulator-
FHG68_RS2118070719..70949-231WP_004497519.1hypothetical protein-
FHG68_RS2118571109..71905-797Protein_68IS5 family transposase-
FHG68_RS2119072072..72275-204WP_004497508.1hypothetical protein-
FHG68_RS2120072651..73289-639WP_004499330.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..9548795487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(11-111)

Antitoxin

SpoVT-AbrB domain

(6-48)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12905.17 Da        Isoelectric Point: 10.1024

>T127098 WP_016758353.1 NZ_CP040845:c68258-67917 [Leptospira weilii]
MVKSRKYTPEKGDIVWLNFTPQAGHEQKGRRPALVLSPKEYNSKTGLAIFCPITSKIKGYPFEVTIKLKKIDGVILSDQV
KNLDWTIREAEFIESINKVSLKEVLDNIKLLVF

Download         Length: 342 bp

>T127098 NZ_CP040845:c68258-67917 [Leptospira weilii]
TTGGTAAAGAGTAGAAAATATACTCCTGAAAAAGGAGATATAGTTTGGCTGAACTTTACCCCGCAAGCAGGTCATGAACA
AAAAGGTCGTAGACCAGCTTTAGTTTTGTCACCTAAAGAATATAATTCGAAAACTGGATTAGCAATTTTCTGTCCGATTA
CTAGTAAGATTAAAGGTTATCCATTCGAGGTAACAATTAAATTGAAGAAAATTGATGGTGTAATTCTTTCTGATCAAGTG
AAAAACTTAGACTGGACTATTCGTGAAGCTGAATTTATAGAATCAATAAATAAAGTTTCTTTGAAAGAAGTTTTAGATAA
TATTAAGTTATTAGTATTTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8756.06 Da        Isoelectric Point: 7.2016

>AT127098 WP_004499620.1 NZ_CP040845:c68488-68252 [Leptospira weilii]
MESIIQKWGNSLGIRIPKAMATELELNDGSHVELQYEGNKIVIYPMKKASLEEKLSKITKQNLHSEISTGNSIGKEAW

Download         Length: 237 bp

>AT127098 NZ_CP040845:c68488-68252 [Leptospira weilii]
ATGGAATCAATTATTCAAAAATGGGGTAATAGCTTAGGAATTAGAATTCCAAAAGCAATGGCAACGGAATTAGAGTTAAA
TGACGGAAGCCACGTTGAATTACAATATGAAGGGAATAAGATTGTAATATATCCAATGAAAAAAGCTTCATTAGAAGAAA
AACTTTCTAAAATTACGAAACAAAATCTTCACTCTGAAATATCAACTGGTAACTCAATAGGTAAAGAAGCTTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A828Z2G4

References