Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/PemK(toxin)
Location 758628..759204 Replicon chromosome
Accession NZ_CP040840
Organism Leptospira weilii strain CUDO6

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag FHG67_RS03615 Protein ID WP_016758518.1
Coordinates 758863..759204 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID M6QGN1
Locus tag FHG67_RS03610 Protein ID WP_004495460.1
Coordinates 758628..758876 (+) Length 83 a.a.

Genomic Context

FHG67_RS03600FHG67_RS21630FHG67_RS03605FHG67_RS03610FHG67_RS03615FHG67_RS21635FHG67_RS03625FHG67_RS03630FHG67_RS03590FHG67_RS03635FHG67_RS03640
Location: 757767..758039 (273 bp)
Type: Others
Protein ID: WP_036075712.1
Location: 758036..758197 (162 bp)
Type: Others
Protein ID: WP_004499288.1
Location: 758229..758492 (264 bp)
Type: Others
Protein ID: WP_142499899.1
Location: 758628..758876 (249 bp)
Type: Antitoxin
Protein ID: WP_004495460.1
Location: 758863..759204 (342 bp)
Type: Toxin
Protein ID: WP_016758518.1
Location: 759481..759750 (270 bp)
Type: Others
Protein ID: WP_036075696.1
Location: 759740..760162 (423 bp)
Type: Others
Protein ID: WP_004499259.1
Location: 760493..761086 (594 bp)
Type: Others
Protein ID: WP_004501734.1
Location: 754908..756101 (1194 bp)
Type: Others
Protein ID: WP_004499273.1
Location: 761393..762592 (1200 bp)
Type: Others
Protein ID: WP_004501723.1
Location: 762596..763300 (705 bp)
Type: Others
Protein ID: WP_004501733.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FHG67_RS03590754908..756101-1194WP_004499273.1M23 family metallopeptidase-
FHG67_RS03600757767..758039+273WP_036075712.1transposase-
FHG67_RS21630758036..758197+162WP_004499288.1transposase-
FHG67_RS03605758229..758492+264WP_142499899.1IS3 family transposase-
FHG67_RS03610758628..758876+249WP_004495460.1hypothetical proteinAntitoxin
FHG67_RS03615758863..759204+342WP_016758518.1type II toxin-antitoxin system PemK/MazF family toxinToxin
FHG67_RS21635759481..759750+270WP_036075696.1hypothetical protein-
FHG67_RS03625759740..760162+423WP_004499259.1PIN domain-containing protein-
FHG67_RS03630760493..761086+594WP_004501734.1dihydrofolate reductase family protein-
FHG67_RS03635761393..762592-1200WP_004501723.1membrane protein-
FHG67_RS03640762596..763300-705WP_004501733.1glycosyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12451.35 Da        Isoelectric Point: 8.6144

>T127093 WP_016758518.1 NZ_CP040840:758863-759204 [Leptospira weilii]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVLISKKDSNLSKDSVVNVSQIV
TLDKKRFLNKVGKLKSNKLNEVEAGLKLVTDLD

Download         Length: 342 bp

>T127093 NZ_CP040840:758863-759204 [Leptospira weilii]
ATGATTCGTGGTGAAATTTGGTGGGTAGACTTGGGAATTCCCTTTGGAAGTGAGCCAGGATTCAAACGTCCGGTTTTGAT
AATTCAAGATGACTCTTTTAATCAAAGTAATATTAATACAATAGTTTCGATTGCAATTACATCGAATTTAAATCTATCCG
AAGCACCAGGTAACGTTTTAATTAGTAAGAAAGATTCGAATTTATCAAAGGATTCAGTCGTAAATGTCTCTCAAATTGTG
ACTTTAGATAAAAAAAGATTTCTTAATAAAGTAGGAAAACTTAAATCCAATAAACTAAATGAAGTTGAAGCGGGGCTAAA
GTTAGTTACAGACTTAGATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9287.59 Da        Isoelectric Point: 10.1669

>AT127093 WP_004495460.1 NZ_CP040840:758628-758876 [Leptospira weilii]
MKTAISIPDELFKTAEKTAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKVYNSKSSETKNNITDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT127093 NZ_CP040840:758628-758876 [Leptospira weilii]
ATGAAAACGGCAATCTCAATTCCTGATGAGCTATTTAAGACCGCAGAAAAAACAGCTAAAAAGCTTGGTATTCCTCGTAG
TCAGTTATTTGCAAAAGCATTAGAGGAATTTATTCAATCTCATAGTAAAGAATCCGTAACTGAGAAATTAAATAAAGTCT
ACAATAGTAAATCTAGCGAAACTAAAAATAACATCACTGACTTATCCGTAGAATCACTTCGCAAAAGTTTAAAAAATGAT
TCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBM6QGN1

References