Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4885740..4886256 Replicon chromosome
Accession NZ_CP040833
Organism Klebsiella pneumoniae strain SH12

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag FHY43_RS24075 Protein ID WP_002886902.1
Coordinates 4885740..4886024 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FHY43_RS24080 Protein ID WP_002886901.1
Coordinates 4886014..4886256 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHY43_RS24050 (FHY43_24285) 4881224..4881487 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
FHY43_RS24055 4881617..4881790 + 174 WP_002886906.1 hypothetical protein -
FHY43_RS24060 (FHY43_24290) 4881793..4882536 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FHY43_RS24065 (FHY43_24295) 4882893..4885031 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
FHY43_RS24070 (FHY43_24300) 4885272..4885736 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FHY43_RS24075 (FHY43_24305) 4885740..4886024 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FHY43_RS24080 (FHY43_24310) 4886014..4886256 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FHY43_RS24085 (FHY43_24315) 4886334..4888244 - 1911 WP_004152270.1 PRD domain-containing protein -
FHY43_RS24090 (FHY43_24320) 4888267..4889421 - 1155 WP_002886900.1 lactonase family protein -
FHY43_RS24095 (FHY43_24325) 4889487..4890227 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T127079 WP_002886902.1 NZ_CP040833:c4886024-4885740 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T127079 NZ_CP040833:c4886024-4885740 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT127079 WP_002886901.1 NZ_CP040833:c4886256-4886014 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT127079 NZ_CP040833:c4886256-4886014 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References