Detailed information of TA system TA127062

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2834585..2835223
• Replicon: chromosome
• Accession: NZ_CP040818
• Organism: Paraoceanicella profunda strain D4M1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FDP22_RS12680
• Protein ID: WP_138574137.1
• Coordinates: 2835041..2835223 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FDP22_RS12675
• Protein ID: WP_138574136.1
• Coordinates: 2834585..2834983 (-)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDP22_RS12645	2830051..2830881	+	831	WP_138574125.1	hypothetical protein	-
FDP22_RS12650	2831058..2831783	+	726	WP_138574127.1	hypothetical protein	-
FDP22_RS12655	2831816..2832445	+	630	WP_138574128.1	hypothetical protein	-
FDP22_RS12660	2832438..2832962	+	525	WP_138574130.1	hypothetical protein	-
FDP22_RS12665	2833107..2833355	+	249	WP_138574132.1	hypothetical protein	-
FDP22_RS12670	2833350..2834249	-	900	WP_170317686.1	serine protease	-
FDP22_RS12675	2834585..2834983	-	399	WP_138574136.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FDP22_RS12680	2835041..2835223	-	183	WP_138574137.1	type II toxin-antitoxin system HicA family toxin	Toxin
FDP22_RS12685	2835515..2835997	+	483	WP_138574138.1	thermonuclease family protein	-
FDP22_RS12690	2836519..2836815	-	297	WP_138574139.1	hypothetical protein	-
FDP22_RS12695	2837865..2838641	-	777	WP_205910781.1	SDR family NAD(P)-dependent oxidoreductase	-
FDP22_RS12700	2838757..2839308	+	552	WP_138574141.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2793487..2835997	42510

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6690.83 Da
• Isoelectric Point: 11.9924

>T127062 WP_138574137.1 NZ_CP040818:c2835223-2835041 [Paraoceanicella profunda]
MEKNSKAIIARLQKEGFTVVSQRGSHVKLRKGDRTVIVPHPKRDLPTGTARNIAKQAGWI

Nucleotide

• Length: 183 bp

>T127062 NZ_CP040818:c2835223-2835041 [Paraoceanicella profunda]
ATGGAGAAGAATTCAAAGGCGATCATCGCCCGGCTCCAGAAGGAAGGCTTCACCGTGGTTTCGCAGAGGGGATCGCACGT
GAAGCTGAGGAAAGGAGACCGGACGGTTATCGTCCCCCACCCGAAGCGGGATCTGCCAACAGGCACAGCCCGCAACATAG
CGAAGCAGGCGGGCTGGATTTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14242.99 Da
• Isoelectric Point: 4.1775

>AT127062 WP_138574136.1 NZ_CP040818:c2834983-2834585 [Paraoceanicella profunda]
MIYWAIVHHDPGSAYGVSFPDVPDCFAAADEEEDLMANAIAALDDYFADGHVMPAASGLEQVRAAVAEDLAEGAFLVQVP
AIRRLTKTVRANISMEQGLLEAIDEAAEQLDMNRSAFLAQAARNEIHRTKAA

Nucleotide

• Length: 399 bp

>AT127062 NZ_CP040818:c2834983-2834585 [Paraoceanicella profunda]
ATGATCTACTGGGCCATTGTCCACCACGACCCGGGAAGCGCCTACGGCGTTTCCTTCCCGGATGTGCCGGACTGCTTTGC
AGCAGCCGACGAAGAAGAGGATCTGATGGCCAATGCCATCGCGGCTCTCGACGACTACTTCGCCGACGGCCATGTGATGC
CCGCAGCCAGCGGCCTCGAGCAGGTGCGCGCGGCTGTCGCCGAGGATCTCGCCGAGGGCGCATTCCTCGTCCAGGTTCCG
GCGATCCGCCGCCTCACCAAGACGGTGCGAGCGAATATCAGCATGGAGCAAGGCCTGCTCGAAGCCATCGATGAAGCAGC
GGAGCAGCTCGACATGAACCGCTCCGCCTTCCTGGCGCAGGCGGCCAGAAACGAGATCCACCGCACGAAAGCGGCCTGA