Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3265896..3267484 Replicon chromosome
Accession NZ_CP040817
Organism Dickeya zeae strain PL65

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FGI21_RS14625 Protein ID WP_220177079.1
Coordinates 3266165..3267484 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FGI21_RS14620 Protein ID WP_168364151.1
Coordinates 3265896..3266165 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGI21_RS14595 (FGI21_14735) 3261241..3261852 - 612 WP_220177076.1 NAD(P)-dependent oxidoreductase -
FGI21_RS14600 (FGI21_14740) 3261995..3262381 + 387 WP_168363927.1 helix-turn-helix domain-containing protein -
FGI21_RS14605 (FGI21_14745) 3262518..3263606 - 1089 WP_168363926.1 4-hydroxyphenylpyruvate dioxygenase -
FGI21_RS14610 (FGI21_14750) 3263925..3264698 + 774 WP_220177077.1 MBL fold metallo-hydrolase -
FGI21_RS14615 (FGI21_14755) 3264742..3265719 + 978 WP_220177078.1 helix-turn-helix domain-containing protein -
FGI21_RS14620 (FGI21_14760) 3265896..3266165 + 270 WP_168364151.1 helix-turn-helix domain-containing protein Antitoxin
FGI21_RS14625 (FGI21_14765) 3266165..3267484 + 1320 WP_220177079.1 type II toxin-antitoxin system HipA family toxin Toxin
FGI21_RS14630 (FGI21_14770) 3267517..3268881 - 1365 WP_220177080.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
FGI21_RS14635 (FGI21_14775) 3268998..3270629 - 1632 WP_219952228.1 membrane protein insertase YidC -
FGI21_RS14640 (FGI21_14780) 3270632..3270889 - 258 WP_012886807.1 membrane protein insertion efficiency factor YidD -
FGI21_RS14645 (FGI21_14785) 3270853..3271212 - 360 WP_012886808.1 ribonuclease P protein component -
FGI21_RS14650 (FGI21_14790) 3271231..3271371 - 141 WP_000831330.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49423.71 Da        Isoelectric Point: 7.0977

>T127060 WP_220177079.1 NZ_CP040817:3266165-3267484 [Dickeya zeae]
MAALDVYMNGYRVGILTKTGSGAHHFSYDVNWLGLSGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLAKVGRDSVGALQLIPASTPTNNIKQIEYKTLSEQQLENILSGYLVDAPLGMIDTEDDFRISIAGAQEKTA
LLYRDNHWCLPFNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAREFGLPVPHCFMLKAGKIKALAVERFDRK
YASDGSWVMRLPQEDFCQVFNVPSALKYENHGGPGISAIMSYLLGAVDPQRDRYSFMKVQVLFWLLAATDGHAKNFSLFI
EPEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLASSKGKKYAIEQIFPRHFFQTAQVVGFARESMESILTEFAQSM
DTIVMKIRNQLPASFPASIRDAILEGMQARAGRLMTGWE

Download         Length: 1320 bp

>T127060 NZ_CP040817:3266165-3267484 [Dickeya zeae]
ATGGCTGCGCTCGATGTCTACATGAACGGTTATCGGGTGGGGATATTGACCAAAACAGGTAGTGGGGCACATCATTTTTC
CTATGATGTGAACTGGCTTGGGTTGTCGGGAAGTCGCCCTATCTCACTCTCTATGCCACTACGTCATCAGCCCTATCAAG
GTGATGAAGTTTATAACTTCTTCGACAATTTGTTGCCGGATAATCCGGACATCAGAAGACGAATTGTTGCCAGGCATCAC
GCTGACTCCACCCAGCCGTTTGATCTGCTGGCTAAAGTGGGGCGAGACAGTGTTGGGGCGTTGCAATTGATACCGGCGAG
TACACCAACTAACAATATAAAACAGATTGAATACAAAACATTATCTGAGCAGCAGCTTGAAAACATACTGTCGGGATATC
TGGTTGATGCGCCGCTGGGGATGATTGATACAGAAGATGATTTTCGTATCTCTATTGCTGGCGCACAGGAAAAGACGGCT
CTGCTTTATCGGGATAATCACTGGTGCCTGCCCTTCAATACCACACCCACTACCCACATCATCAAGCTACCGATTGGTAA
AATCGAGAGTCACTCTTACTCCATTGATATGTCTGACAGCGTTGAAAATGAGTATCTGTGCCTGCTGATTGCCAGGGAGT
TTGGGCTACCGGTGCCACACTGTTTTATGCTCAAAGCTGGCAAGATAAAAGCGCTGGCGGTAGAACGTTTTGATCGTAAA
TATGCCTCGGATGGCAGTTGGGTTATGCGATTGCCACAGGAGGATTTTTGTCAGGTATTCAACGTGCCTTCCGCACTGAA
ATATGAAAATCATGGTGGGCCCGGTATTTCCGCCATTATGTCGTATCTATTAGGCGCTGTTGACCCACAAAGGGATCGCT
ATAGTTTTATGAAGGTTCAGGTGCTGTTCTGGCTATTGGCAGCAACAGATGGTCATGCGAAGAATTTTTCCTTGTTTATT
GAGCCTGAGGGACGATATCGCCTCACGCCTTTCTATGACATTCTCTCTATGTACCCGGCGATGGGTGGGCGGGGAATTGA
TCGCAGAGAGGCAAAACTGGCGATGGGGCTGGCTAGCTCAAAAGGCAAGAAATACGCGATTGAGCAGATCTTTCCACGTC
ACTTTTTCCAAACGGCGCAGGTAGTTGGGTTTGCCAGAGAATCAATGGAGAGCATTCTGACGGAATTTGCACAGTCGATG
GATACGATTGTGATGAAAATTAGGAACCAACTACCTGCGAGTTTTCCTGCATCTATTCGCGATGCAATTCTCGAAGGCAT
GCAGGCAAGAGCGGGGCGATTAATGACCGGGTGGGAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10008.27 Da        Isoelectric Point: 8.5848

>AT127060 WP_168364151.1 NZ_CP040817:3265896-3266165 [Dickeya zeae]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTSRNMDAANNEASV
AESSWKEEW

Download         Length: 270 bp

>AT127060 NZ_CP040817:3265896-3266165 [Dickeya zeae]
ATGAAGGTCACCAACAGCAAACAGCTTAGCAGCTATCTGAAAGATGTTCGTATCACGCAGAAGCTTTCACAAGGAAAAGT
GGCCAGTAAAGTGGGTATTCGCCAGGATACGGTATCCAGCTTTGAACAACATCCTGATTCCACCAAACTGGAAACCTTCT
TTAAAATCCTATCGGCATTAAATTTAGAACTTACGGTTACCTCCAGGAATATGGATGCCGCCAATAACGAGGCCTCTGTT
GCAGAATCGTCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References