127057

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/dnstrm_HI1420(antitoxin)
Location 1468050..1468800 Replicon chromosome
Accession NZ_CP040817
Organism Dickeya zeae strain PL65

Toxin (Protein)


Gene name dhiT Uniprot ID -
Locus tag FGI21_RS06655 Protein ID WP_168362935.1
Coordinates 1468543..1468800 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID -
Locus tag FGI21_RS06650 Protein ID WP_168362934.1
Coordinates 1468050..1468535 (-) Length 162 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGI21_RS06625 (FGI21_06660) 1463973..1465700 + 1728 WP_168362930.1 hydrogenase large subunit -
FGI21_RS06630 (FGI21_06665) 1465711..1466280 + 570 WP_016943631.1 hydrogenase 4 subunit H -
FGI21_RS06635 (FGI21_06670) 1466277..1467065 + 789 WP_168362931.1 NADH-quinone oxidoreductase subunit B family protein -
FGI21_RS06640 (FGI21_06675) 1467065..1467463 + 399 WP_168362932.1 formate hydrogenlyase maturation HycH family protein -
FGI21_RS06645 (FGI21_06680) 1467456..1467965 + 510 WP_220178065.1 hydrogenase maturation peptidase HycI -
FGI21_RS06650 (FGI21_06685) 1468050..1468535 - 486 WP_168362934.1 addiction module antitoxin Antitoxin
FGI21_RS06655 (FGI21_06690) 1468543..1468800 - 258 WP_168362935.1 DUF4160 domain-containing protein Toxin
FGI21_RS06660 (FGI21_06695) 1469365..1469907 + 543 WP_016943624.1 4Fe-4S dicluster domain-containing protein -
FGI21_RS06665 (FGI21_06700) 1469942..1472092 + 2151 WP_219952937.1 formate dehydrogenase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-73)

Antitoxin

Uncharacterized protein HI1420

(80-156)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9865.48 Da        Isoelectric Point: 7.5161

>T127057 WP_168362935.1 NZ_CP040817:c1468800-1468543 [Dickeya zeae]
MPEIDRLAGLIFYLYFYDDERHHLPHVHVCYGNHELIISIRTGTEIEGYLPNTKRKLAIAHIMAHREQLLSMWAQAVIGK
NPGKL

Download         Length: 258 bp

>T127057 NZ_CP040817:c1468800-1468543 [Dickeya zeae]
ATGCCTGAGATTGACAGACTGGCAGGGTTAATCTTCTATTTGTACTTTTACGATGATGAGCGGCACCACTTGCCGCATGT
GCATGTCTGCTACGGCAATCATGAACTTATCATCAGTATTCGTACCGGAACCGAGATAGAGGGATATCTGCCAAATACCA
AACGTAAGCTGGCGATTGCCCATATCATGGCGCATCGTGAGCAATTGCTGAGTATGTGGGCACAGGCGGTTATCGGGAAG
AATCCGGGAAAATTGTGA

Antitoxin


Download         Length: 162 a.a.        Molecular weight: 17779.04 Da        Isoelectric Point: 6.8503

>AT127057 WP_168362934.1 NZ_CP040817:c1468535-1468050 [Dickeya zeae]
MHKIVDVDVTGDFSLRLTYDDGLISDVNLYHYASHSVFSHASQFIRFGLLPDGSLEWPDITLSSSALREKGTYVGHTLAV
RERNFADIISRAFYDAVIENRPEILQAALKTAVDKHGNSTVAKEAGAKSRTSLYKSLNKNTNVSLATVVSLAHTVLQLEE
K

Download         Length: 486 bp

>AT127057 NZ_CP040817:c1468535-1468050 [Dickeya zeae]
ATGCATAAGATTGTAGATGTTGACGTGACTGGTGACTTTTCGTTGCGTCTGACTTATGACGATGGCCTGATAAGCGACGT
TAACCTGTATCACTATGCTTCACATTCTGTGTTTTCGCATGCCAGCCAGTTTATTCGATTTGGGTTATTACCTGATGGTT
CGCTGGAATGGCCGGATATCACGCTCTCTTCGTCCGCATTACGGGAAAAGGGGACGTATGTTGGCCACACATTGGCGGTG
AGGGAGCGAAATTTTGCCGATATTATCTCCCGAGCTTTCTATGATGCCGTGATTGAGAACCGGCCAGAAATTCTGCAGGC
GGCGCTGAAAACCGCAGTAGACAAACATGGCAACAGTACGGTGGCCAAAGAAGCGGGAGCCAAAAGCCGTACCAGCTTGT
ATAAATCGCTGAATAAAAACACTAATGTCAGCCTGGCGACGGTAGTTAGCCTGGCCCATACCGTGTTGCAGTTGGAAGAG
AAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References