Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1410437..1411054 Replicon chromosome
Accession NZ_CP040817
Organism Dickeya zeae strain PL65

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FGI21_RS06390 Protein ID WP_023639454.1
Coordinates 1410437..1410616 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FGI21_RS06395 Protein ID WP_220178041.1
Coordinates 1410644..1411054 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGI21_RS06375 (FGI21_06405) 1406540..1407466 + 927 WP_219952968.1 LysR family transcriptional regulator -
FGI21_RS06380 (FGI21_06410) 1407631..1408698 + 1068 WP_219952967.1 MBL fold metallo-hydrolase -
FGI21_RS06385 (FGI21_06415) 1408925..1409986 - 1062 WP_220178040.1 hypothetical protein -
FGI21_RS06390 (FGI21_06420) 1410437..1410616 + 180 WP_023639454.1 type II toxin-antitoxin system HicA family toxin Toxin
FGI21_RS06395 (FGI21_06425) 1410644..1411054 + 411 WP_220178041.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FGI21_RS06400 (FGI21_06430) 1411103..1411726 - 624 WP_220178042.1 RraA family protein -
FGI21_RS06405 (FGI21_06435) 1411723..1412568 - 846 WP_220178390.1 ABC transporter ATP-binding protein -
FGI21_RS06410 (FGI21_06440) 1412580..1413629 - 1050 WP_220178043.1 iron ABC transporter permease -
FGI21_RS06415 (FGI21_06445) 1413622..1414644 - 1023 WP_258570093.1 iron ABC transporter permease -
FGI21_RS06420 (FGI21_06450) 1414641..1415558 - 918 WP_220178044.1 iron-siderophore ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6544.69 Da        Isoelectric Point: 10.7838

>T127056 WP_023639454.1 NZ_CP040817:1410437-1410616 [Dickeya zeae]
MDSRTLMAEIKADGWELVRINGSHHHFIHPAKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T127056 NZ_CP040817:1410437-1410616 [Dickeya zeae]
ATGGACAGCAGGACGTTAATGGCAGAAATCAAGGCCGATGGATGGGAATTGGTAAGGATTAACGGCAGCCATCACCACTT
CATCCACCCAGCTAAACCGGGGTTAGTCACCATCCCGCATCCTAAGAAGGATTTACCGATAGGCACGGTAAAAAGCATCA
GGAAACAGGCAGGGATATGA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14525.56 Da        Isoelectric Point: 4.3391

>AT127056 WP_220178041.1 NZ_CP040817:1410644-1411054 [Dickeya zeae]
MFYPIAIEAGDDAHAYGVTVPDLPGCFSAGDTLDEAIANAKDAITGHIELLIEMGQDIPAVSSVGTLAKSPEYIGYTWAV
VDIDVTRLMGGVEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSLR

Download         Length: 411 bp

>AT127056 NZ_CP040817:1410644-1411054 [Dickeya zeae]
ATGTTTTATCCAATTGCAATTGAAGCAGGCGACGATGCTCATGCATACGGCGTAACAGTGCCAGATCTACCGGGCTGTTT
CTCCGCAGGTGATACACTTGATGAGGCCATCGCCAACGCTAAAGACGCGATCACTGGTCACATTGAGCTGCTGATCGAAA
TGGGGCAGGATATTCCTGCTGTTTCATCCGTCGGCACGTTGGCGAAATCACCGGAATACATCGGTTACACCTGGGCCGTT
GTTGATATCGATGTCACCCGGCTGATGGGGGGTGTGGAAAAAATTAACGTCACGCTGCCGAAATCACTGATTGACCGTAT
CGATCGTTGCGTAGCAAGTAACCCAGAATTTAAAAGCCGCTCGGGGTTTCTTGCCCAGGCGGCATTAGAGCGAATTTCAT
CCCTGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References