Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 118670..119223 Replicon chromosome
Accession NZ_CP040817
Organism Dickeya zeae strain PL65

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag FGI21_RS00465 Protein ID WP_220177595.1
Coordinates 118909..119223 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag FGI21_RS00460 Protein ID WP_220177594.1
Coordinates 118670..118906 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGI21_RS00445 (FGI21_00455) 114039..115814 - 1776 WP_220177591.1 ATP-binding protein -
FGI21_RS00450 (FGI21_00460) 115811..116959 - 1149 WP_220177592.1 SIR2 family protein -
FGI21_RS00455 (FGI21_00465) 117485..118429 + 945 WP_220177593.1 zincin-like metallopeptidase domain-containing protein -
FGI21_RS00460 (FGI21_00470) 118670..118906 + 237 WP_220177594.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
FGI21_RS00465 (FGI21_00475) 118909..119223 + 315 WP_220177595.1 CcdB family protein Toxin
FGI21_RS00470 (FGI21_00480) 119220..119399 - 180 WP_258570075.1 mobilization protein mobC -
FGI21_RS00475 (FGI21_00485) 119437..120336 - 900 WP_220177596.1 AraC family transcriptional regulator -
FGI21_RS00480 (FGI21_00490) 120537..120887 + 351 Protein_95 transposase -
FGI21_RS00485 (FGI21_00495) 121044..122765 - 1722 WP_220177597.1 hypothetical protein -
FGI21_RS00495 (FGI21_00500) 122996..123766 - 771 WP_258570076.1 VirB3 family type IV secretion system protein -
FGI21_RS00500 (FGI21_00505) 123777..124052 - 276 WP_012769221.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 113521..113895 374


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11502.40 Da        Isoelectric Point: 7.9859

>T127046 WP_220177595.1 NZ_CP040817:118909-119223 [Dickeya zeae]
MQFTVYGNTGKSAIYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
SVFCDASQYRNQVKAAIDFLIDGI

Download         Length: 315 bp

>T127046 NZ_CP040817:118909-119223 [Dickeya zeae]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGCCATTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
ACAGTTAAATCGTCGGATAGTGATCCCGTTGCTCCCGGTTGAAAAGTACCCGGCAGGCCGCCGACCGGATCGCCTTGTCC
CCGTCGTCAGGCTGACGGACGGCAAAGAATACGCCGTAATGACTCACGAGCTGGCAAGTATTCCTGTGCAGGCTCTGGGG
TCGGTGTTTTGTGATGCGTCGCAGTACCGTAATCAGGTAAAGGCCGCAATAGATTTCCTCATTGACGGCATTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9020.02 Da        Isoelectric Point: 5.6998

>AT127046 WP_220177594.1 NZ_CP040817:118670-118906 [Dickeya zeae]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELHRYEAKKWQEENREAIDALNRFHDENGCFSDEYRTF

Download         Length: 237 bp

>AT127046 NZ_CP040817:118670-118906 [Dickeya zeae]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACGGTAGAGCGTGCCTTACTGGTCCGGGCGCGTGAAGCGGG
CATTAACCTGAGTGCCACCCTGTCAACCGCCCTGGATGCAGAGCTTCACCGTTATGAAGCGAAAAAATGGCAGGAAGAGA
ACAGGGAAGCCATCGACGCATTAAATCGCTTTCATGATGAAAACGGCTGCTTCAGTGACGAATACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References