Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4171508..4172034 Replicon chromosome
Accession NZ_CP040815
Organism Dickeya zeae strain A5272

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag FGI00_RS18405 Protein ID WP_248588438.1
Coordinates 4171729..4172034 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag FGI00_RS18400 Protein ID WP_248588437.1
Coordinates 4171508..4171726 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGI00_RS18375 (FGI00_18590) 4166669..4167970 + 1302 WP_248588435.1 anaerobic C4-dicarboxylate transporter -
FGI00_RS18380 (FGI00_18595) 4168085..4168447 + 363 WP_023638867.1 divalent cation tolerance protein CutA -
FGI00_RS18385 (FGI00_18600) 4168423..4170171 + 1749 WP_248588436.1 protein-disulfide reductase DsbD -
FGI00_RS18390 (FGI00_18605) 4170264..4170839 + 576 WP_248589836.1 transcriptional regulator -
FGI00_RS18400 (FGI00_18615) 4171508..4171726 + 219 WP_248588437.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
FGI00_RS18405 (FGI00_18620) 4171729..4172034 + 306 WP_248588438.1 type II toxin-antitoxin system toxin CcdB Toxin
FGI00_RS18410 (FGI00_18625) 4172173..4172667 - 495 WP_248588439.1 GNAT family N-acetyltransferase -
FGI00_RS18415 (FGI00_18630) 4172664..4172957 - 294 WP_248588440.1 DUF1778 domain-containing protein -
FGI00_RS18420 (FGI00_18635) 4173154..4173840 - 687 WP_248588441.1 DUF5710 domain-containing protein -
FGI00_RS18425 (FGI00_18640) 4174298..4174798 - 501 WP_248588442.1 serine acetyltransferase -
FGI00_RS18430 (FGI00_18645) 4174828..4176222 - 1395 WP_248588443.1 DUF4832 domain-containing protein -
FGI00_RS18435 (FGI00_18650) 4176260..4176667 - 408 WP_226099917.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11610.35 Da        Isoelectric Point: 4.4047

>T127044 WP_248588438.1 NZ_CP040815:4171729-4172034 [Dickeya zeae]
MQFIVYEYKRASHYKMFVDVQSDLVDTPGRRMVIPLIESHHLSEKVNKTLFPLISIDGESYRLMTTELSSVPVEVIGEEI
ADLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T127044 NZ_CP040815:4171729-4172034 [Dickeya zeae]
ATGCAATTCATTGTTTATGAATACAAAAGAGCCAGTCACTACAAAATGTTTGTCGATGTGCAAAGCGATCTTGTCGATAC
GCCAGGGCGGCGCATGGTCATTCCGCTTATCGAATCACATCACCTGTCTGAGAAAGTGAATAAAACATTGTTCCCTCTAA
TCAGCATCGACGGCGAGAGCTATCGACTGATGACCACTGAGCTATCGAGCGTTCCCGTTGAGGTTATTGGTGAAGAGATC
GCGGATCTTGGCGACTACGCGGATGAGATCAAGGATGCTATCAATCTTATGTTTTGGGGGATTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8120.09 Da        Isoelectric Point: 8.6383

>AT127044 WP_248588437.1 NZ_CP040815:4171508-4171726 [Dickeya zeae]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDAIGKEARRIKAEAWKKENREGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT127044 NZ_CP040815:4171508-4171726 [Dickeya zeae]
ATGAAACACCGCGTTAGCGTTACCGTGGACAAAGACAATTATCAGGTTCTGAGTGCTGCCGGAGTCAATATTTCCGGGCT
GGTGAATGACGCCATTGGCAAAGAAGCCCGCCGCATCAAGGCTGAAGCGTGGAAAAAGGAAAACCGCGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCGCAGAATGGCTCCTTTGCGGATGAAAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References