Detailed information of TA system TA127042

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4034969..4035647
• Replicon: chromosome
• Accession: NZ_CP040815
• Organism: Dickeya zeae strain A5272

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: D2BSA8
• Locus tag: FGI00_RS17730
• Protein ID: WP_012883372.1
• Coordinates: 4034969..4035400 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: FGI00_RS17735
• Protein ID: WP_038906203.1
• Coordinates: 4035381..4035647 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGI00_RS17710 (FGI00_17910)	4030916..4031632	-	717	WP_019846265.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
FGI00_RS17715 (FGI00_17915)	4031720..4032619	-	900	WP_110371327.1	site-specific tyrosine recombinase XerD	-
FGI00_RS17720 (FGI00_17920)	4032883..4034208	+	1326	WP_248588379.1	MFS transporter	-
FGI00_RS17725 (FGI00_17925)	4034362..4034880	+	519	WP_248588380.1	flavodoxin FldB	-
FGI00_RS17730 (FGI00_17930)	4034969..4035400	-	432	WP_012883372.1	protein YgfX	Toxin
FGI00_RS17735 (FGI00_17935)	4035381..4035647	-	267	WP_038906203.1	FAD assembly factor SdhE	Antitoxin
FGI00_RS17740 (FGI00_17940)	4035957..4036937	+	981	WP_248588381.1	tRNA-modifying protein YgfZ	-
FGI00_RS17745 (FGI00_17945)	4037014..4037664	-	651	WP_248589833.1	hemolysin III family protein	-
FGI00_RS17750 (FGI00_17950)	4037877..4038485	+	609	WP_038907054.1	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16887.54 Da
• Isoelectric Point: 11.5023

>T127042 WP_012883372.1 NZ_CP040815:c4035400-4034969 [Dickeya zeae]
VAQWQCDLRVSWRMQLFSLLTHGFLMLMILLAPWPDGYAPLWLGLVTLVVFDFVRSQRSIKSRQGEISLRGDNQLHWQQR
DWQIVRRPWFMRNGVLLSLRAVDGKGQQRLWLASDSMGSEEWRLLRQQLQQPALHGTESSRHH

Nucleotide

• Length: 432 bp

>T127042 NZ_CP040815:c4035400-4034969 [Dickeya zeae]
GTGGCCCAGTGGCAATGTGATTTACGCGTATCCTGGCGCATGCAGTTGTTTTCGTTGCTAACGCACGGATTTCTGATGCT
GATGATCCTGCTGGCTCCCTGGCCGGACGGCTACGCACCGCTGTGGCTCGGGTTAGTGACGCTGGTCGTATTTGACTTTG
TGCGTAGCCAGCGAAGCATCAAATCGCGCCAGGGGGAGATTTCCCTGCGTGGCGATAACCAACTGCACTGGCAGCAACGT
GACTGGCAGATTGTCCGGCGACCGTGGTTCATGCGCAATGGCGTATTGTTATCGCTACGTGCGGTGGATGGTAAAGGGCA
ACAGCGTTTGTGGCTGGCGTCAGACAGTATGGGGAGTGAGGAATGGCGGCTGTTACGTCAACAGCTGCAGCAGCCTGCGC
TGCATGGAACGGAATCTTCCCGCCATCATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10446.96 Da
• Isoelectric Point: 5.5981

>AT127042 WP_038906203.1 NZ_CP040815:c4035647-4035381 [Dickeya zeae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQQFIRLLQCDDPDLFNWLMNHGEPVDPGLKRMVSLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT127042 NZ_CP040815:c4035647-4035381 [Dickeya zeae]
ATGGACATCAATAACAAAGCACGTATTCACTGGGCGTGCAGGCGTGGAATGCGCGAACTGGACATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGATACGCTGAGCGACGACGACAAACAGCAGTTTATTCGTCTGCTGCAGTGTGACGATCCTGACT
TGTTTAATTGGTTGATGAACCACGGCGAGCCGGTTGATCCCGGTTTGAAGCGGATGGTTTCCCTTATTCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA

Structures

Toxin

• AlphaFold DB: A0A2K9QB06