Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3574697..3575322 Replicon chromosome
Accession NZ_CP040815
Organism Dickeya zeae strain A5272

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag FGI00_RS15665 Protein ID WP_009114000.1
Coordinates 3575119..3575322 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D2BUK3
Locus tag FGI00_RS15660 Protein ID WP_012883774.1
Coordinates 3574697..3575065 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGI00_RS15645 (FGI00_15825) 3570455..3573601 + 3147 WP_019844634.1 efflux RND transporter permease subunit -
FGI00_RS15650 (FGI00_15830) 3573777..3574028 + 252 WP_019844635.1 type B 50S ribosomal protein L31 -
FGI00_RS15655 (FGI00_15835) 3574044..3574187 + 144 WP_012770724.1 type B 50S ribosomal protein L36 -
FGI00_RS15660 (FGI00_15840) 3574697..3575065 + 369 WP_012883774.1 Hha toxicity modulator TomB Antitoxin
FGI00_RS15665 (FGI00_15845) 3575119..3575322 + 204 WP_009114000.1 HHA domain-containing protein Toxin
FGI00_RS15675 (FGI00_15855) 3575872..3576198 + 327 WP_012883773.1 MGMT family protein -
FGI00_RS15680 (FGI00_15860) 3576239..3576820 - 582 WP_023639172.1 YbaY family lipoprotein -
FGI00_RS15685 (FGI00_15865) 3577038..3577901 + 864 WP_023639171.1 acyl-CoA thioesterase II -
FGI00_RS15690 (FGI00_15870) 3578022..3579314 - 1293 WP_023639170.1 ammonium transporter AmtB -
FGI00_RS15695 (FGI00_15875) 3579358..3579696 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T127041 WP_009114000.1 NZ_CP040815:3575119-3575322 [Dickeya zeae]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

>T127041 NZ_CP040815:3575119-3575322 [Dickeya zeae]
ATGAAAAAAATCGACTATTTAATGCGTTTGCGTAAATGTACAACCATCGACACGCTTGAGCGTGTTATAGAAAAAAACAA
GTACGAGCTTTCTAACGACGAACTTGAAATGTTCTATTCAGCTGCAGACCATCGTCTGGCTGAGCTAACGATGAATAAAC
TTTACGACAAAGTGCCAACTGCCGTGTGGAAATACGTTCGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14186.04 Da        Isoelectric Point: 5.1811

>AT127041 WP_012883774.1 NZ_CP040815:3574697-3575065 [Dickeya zeae]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDSELQKWKKSKSQLFRMFSEKSVCTVVKT

Download         Length: 369 bp

>AT127041 NZ_CP040815:3574697-3575065 [Dickeya zeae]
ATGGATGAGTACACACCTCAACATTATGATATTGCCCAACTCAGATTCTTGTGTGAAAATCTGCACGACGAAAGTATCGC
AACATTAGGTGACAGCAGTCGTGGCTGGGTGAATGATCCGACCTCTGCGGTCAATCTTCAACTAAACGAACTTATCGAAC
ACATTGCGGCATTTGTTGTTACCTACAAAATAAAATATCCGCATGAAGCGGCGCTGTGTGAGCGGGTTGAAAAATACCTG
GACGATACTTATATTCTTTTCAGCAACTACGGTATAAATGATTCAGAGTTGCAGAAATGGAAAAAATCCAAGTCGCAATT
ATTCAGAATGTTCTCAGAAAAGAGCGTCTGTACGGTAGTAAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure
AlphaFold DB A0A2K9QCC2

References