Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 92051..93639 Replicon chromosome
Accession NZ_CP040815
Organism Dickeya zeae strain A5272

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FGI00_RS00440 Protein ID WP_248588712.1
Coordinates 92320..93639 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FGI00_RS00435 Protein ID WP_248589731.1
Coordinates 92051..92320 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGI00_RS00410 (FGI00_00410) 87387..87998 - 612 WP_248588708.1 NAD(P)-dependent oxidoreductase -
FGI00_RS00415 (FGI00_00415) 88141..88527 + 387 WP_168363927.1 helix-turn-helix domain-containing protein -
FGI00_RS00420 (FGI00_00420) 88683..89771 - 1089 WP_248588709.1 4-hydroxyphenylpyruvate dioxygenase -
FGI00_RS00425 (FGI00_00425) 90092..90883 + 792 WP_248588710.1 MBL fold metallo-hydrolase -
FGI00_RS00430 (FGI00_00430) 90927..91904 + 978 WP_248588711.1 helix-turn-helix domain-containing protein -
FGI00_RS00435 (FGI00_00435) 92051..92320 + 270 WP_248589731.1 helix-turn-helix domain-containing protein Antitoxin
FGI00_RS00440 (FGI00_00440) 92320..93639 + 1320 WP_248588712.1 type II toxin-antitoxin system HipA family toxin Toxin
FGI00_RS00445 (FGI00_00445) 93672..95036 - 1365 WP_248588713.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
FGI00_RS00450 (FGI00_00450) 95154..96785 - 1632 WP_016941623.1 membrane protein insertase YidC -
FGI00_RS00455 (FGI00_00455) 96788..97045 - 258 WP_012886807.1 membrane protein insertion efficiency factor YidD -
FGI00_RS00460 (FGI00_00460) 97009..97368 - 360 WP_012886808.1 ribonuclease P protein component -
FGI00_RS00465 (FGI00_00465) 97387..97527 - 141 WP_000831330.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49365.65 Da        Isoelectric Point: 7.0048

>T127029 WP_248588712.1 NZ_CP040815:92320-93639 [Dickeya zeae]
MAALDVYMNGYRVGILTKTGSGAHHFSYDVNWLGLPGSRPISLSMPLRHQPYQGEEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLAKVGRDSVGALQLVPPGAPAHNIKQIEYKTLSEQQLENILSGYLVDAPLGMIDTEDDFRISIAGAQEKTA
LLYQDNHWCLPFNTTPTTHIIKLPIGKIESHSYSIDLSDSVENEYLCLLIARAFGLPVPHCFMLRVGKIKALAVERFDRK
YASDGSWIMRLPQEDFCQVFNVPSALKYENHGGPGISAIMSYLLGAVDPQRDRYSFMKAQVLFWLLAATDGHAKNFSLFI
EPEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSKGKKYAIEQIFPRHFFQTAQAVGFARESMESILTEFAQSM
DEIVMKIRHQLPASFPASIRDAILEGMQARAVRLTTGWE

Download         Length: 1320 bp

>T127029 NZ_CP040815:92320-93639 [Dickeya zeae]
ATGGCTGCGCTCGATGTTTACATGAACGGTTATCGGGTGGGGATATTGACCAAAACAGGTAGTGGGGCACATCATTTTTC
CTATGATGTGAACTGGCTTGGGTTGCCGGGAAGTCGTCCCATCTCGCTCTCTATGCCACTACGTCATCAGCCCTATCAAG
GTGAGGAAGTTTATAACTTCTTCGACAATTTGTTGCCGGATAATCCGGACATCAGAAGACGAATTGTTGCCAGGCATCAC
GCTGATTCCACCCAGCCGTTTGATCTGCTGGCTAAAGTGGGGCGAGACAGTGTCGGCGCGTTGCAATTGGTACCGCCGGG
TGCACCAGCGCACAATATAAAACAGATTGAATACAAAACATTATCTGAGCAACAGCTTGAAAACATACTGTCGGGATATC
TGGTTGATGCGCCACTGGGGATGATTGATACAGAAGACGATTTTCGTATCTCTATTGCTGGTGCACAGGAAAAGACGGCG
CTGCTTTATCAGGATAATCACTGGTGTCTGCCTTTCAATACCACACCTACTACCCACATCATTAAGCTACCGATTGGTAA
AATCGAGAGTCACTCTTACTCCATTGATCTGTCTGACAGCGTCGAAAATGAGTATCTGTGCCTGCTGATTGCCAGGGCAT
TTGGGCTACCGGTGCCGCACTGTTTTATGCTCAGAGTTGGCAAGATAAAAGCGCTGGCAGTAGAACGTTTTGATCGTAAA
TATGCCTCGGATGGCAGTTGGATTATGCGGTTGCCACAGGAGGATTTTTGTCAGGTATTCAACGTGCCTTCCGCGCTGAA
ATATGAAAATCATGGTGGACCCGGTATTTCCGCCATTATGTCGTATCTATTAGGTGCTGTTGACCCACAAAGGGATCGCT
ATAGTTTTATGAAGGCTCAGGTGCTGTTTTGGCTATTGGCAGCAACAGATGGTCATGCGAAGAATTTTTCCTTGTTTATT
GAGCCTGAGGGGCGATATCGCCTTACACCTTTCTATGACATTCTCTCTATGTACCCGGCGATGGGCGGGCGGGGAATTGA
TCGCAGAGAGGCAAAACTGGCGATGGGGCTGACCGGCTCAAAAGGCAAGAAATACGCTATTGAGCAGATCTTTCCACGTC
ACTTTTTCCAAACGGCACAGGCAGTTGGGTTTGCCAGAGAATCAATGGAGAGCATTCTGACGGAATTTGCACAGTCGATG
GATGAGATTGTGATGAAAATCAGGCACCAACTGCCAGCGAGTTTTCCTGCATCTATTCGCGATGCAATTCTCGAAGGCAT
GCAGGCAAGAGCGGTGCGATTAACGACTGGGTGGGAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10062.36 Da        Isoelectric Point: 8.5848

>AT127029 WP_248589731.1 NZ_CP040815:92051-92320 [Dickeya zeae]
MKITNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNMDATNNEASV
AESSWKEEW

Download         Length: 270 bp

>AT127029 NZ_CP040815:92051-92320 [Dickeya zeae]
ATGAAGATCACCAACAGCAAACAGCTTAGCAGCTATCTGAAAGATGTTCGTATCACGCAGAAGCTTTCACAAGGGAAAGT
GGCCAGTAAAGTGGGTATTCGTCAGGATACGGTATCCAGCTTTGAACAACATCCTGATTCCACCAAACTGGAAACCTTCT
TTAAAATCCTGTCGGCATTAAATTTAGAACTTACGGTTACCCCCAGGAATATGGACGCCACCAATAACGAGGCCTCTGTT
GCAGAATCGTCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References