127027

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3321017..3322025 Replicon chromosome
Accession NZ_CP040813
Organism Oceanihabitans sp. IOP_32

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag FEZ18_RS13930 Protein ID WP_153268884.1
Coordinates 3321017..3321580 (-) Length 188 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag FEZ18_RS13935 Protein ID WP_153268885.1
Coordinates 3321570..3322025 (-) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FEZ18_RS13905 3317235..3317825 + 591 WP_153268879.1 imidazole glycerol phosphate synthase subunit HisH -
FEZ18_RS13910 3317998..3318732 + 735 WP_153268880.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
FEZ18_RS13915 3318832..3319587 + 756 WP_153268881.1 imidazole glycerol phosphate synthase subunit HisF -
FEZ18_RS13920 3319632..3320225 + 594 WP_153268882.1 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE -
FEZ18_RS13925 3320449..3320982 - 534 WP_153268883.1 DUF2461 domain-containing protein -
FEZ18_RS13930 3321017..3321580 - 564 WP_153268884.1 PIN domain-containing protein Toxin
FEZ18_RS13935 3321570..3322025 - 456 WP_153268885.1 helix-turn-helix domain-containing protein Antitoxin
FEZ18_RS13940 3322508..3323290 - 783 WP_153268886.1 tRNA pseudouridine(38-40) synthase TruA -
FEZ18_RS13945 3323388..3323627 + 240 WP_153268887.1 hypothetical protein -
FEZ18_RS13950 3323516..3323794 + 279 WP_153269128.1 DUF2461 family protein -
FEZ18_RS13955 3324021..3324437 - 417 WP_153268888.1 glyoxalase -
FEZ18_RS13960 3324706..3325074 + 369 WP_153268889.1 acyl-CoA thioesterase -
FEZ18_RS13965 3325300..3326694 + 1395 WP_153268890.1 3-isopropylmalate dehydratase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(80-127)


Sequences

Toxin        


Download         Length: 188 a.a.        Molecular weight: 21688.88 Da        Isoelectric Point: 5.2995

>T127027 WP_153268884.1 NZ_CP040813:c3321580-3321017 [Oceanihabitans sp. IOP_32]
MIHSVRFTCVLDTNVIYPIEIRDLLFWFAHYDLFTPKWSNHIFDEWEDVMIRKGLEDKEIKKRINRANLAFPDALVINYE
PLIEGLTLPDEKDRHVLAAAIKTNANIIVTNNLKDFPNDYLASFGLAAKSADDFIADIIDLNHEKAIEAFKKLVLNRRHP
DLDEFEVLDNLRKNGLIQSANYLHSLI

Download         Length: 564 bp

>T127027 NZ_CP040813:c3321580-3321017 [Oceanihabitans sp. IOP_32]
ATGATTCATAGCGTACGTTTTACTTGTGTTCTTGACACGAATGTTATTTATCCGATAGAAATTAGAGACTTGTTATTTTG
GTTTGCTCATTATGATTTGTTCACGCCAAAATGGAGCAATCATATTTTTGATGAATGGGAAGACGTAATGATTAGAAAAG
GACTAGAAGATAAAGAAATAAAAAAAAGAATTAATAGGGCAAATTTGGCCTTCCCTGATGCACTTGTAATAAATTACGAG
CCTTTAATTGAAGGATTAACTTTACCTGATGAAAAAGATCGACATGTACTGGCTGCCGCAATTAAAACAAATGCAAATAT
TATTGTAACTAATAATTTGAAAGATTTTCCAAATGACTATTTGGCGTCTTTCGGACTGGCTGCGAAATCTGCCGATGATT
TCATTGCAGATATAATAGATTTAAACCACGAAAAAGCAATAGAAGCTTTTAAGAAATTAGTGTTAAATAGAAGACATCCA
GATTTAGATGAGTTTGAAGTTTTAGATAATTTGAGGAAAAATGGTTTAATTCAATCCGCCAATTACTTACATTCACTTAT
TTAA

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 17183.16 Da        Isoelectric Point: 7.2780

>AT127027 WP_153268885.1 NZ_CP040813:c3322025-3321570 [Oceanihabitans sp. IOP_32]
MEYFNDIKKPSKKEQIAAMESYNALAATLEDIHSESLEIEIEETTEKIKIPLKALKLLAKILKATGQGKPISVVPIATEM
TTQAAAELLGCSRPHFVKLLEEGNIPFTMVGRHRRVKFEDVMNYKKKMKLKREQLLIDMMKSDEELGLYDS

Download         Length: 456 bp

>AT127027 NZ_CP040813:c3322025-3321570 [Oceanihabitans sp. IOP_32]
ATGGAATACTTTAACGACATAAAAAAGCCTTCAAAAAAGGAGCAGATTGCAGCAATGGAATCTTATAATGCCCTTGCTGC
CACATTGGAGGATATACATTCTGAAAGTTTAGAAATTGAAATTGAGGAAACTACAGAAAAAATTAAGATTCCTTTAAAAG
CACTTAAGCTTTTAGCTAAAATCTTAAAAGCAACCGGTCAAGGAAAGCCAATTTCCGTAGTCCCTATTGCAACCGAAATG
ACTACACAAGCCGCAGCCGAATTATTGGGCTGTTCAAGACCTCACTTTGTTAAATTATTAGAGGAAGGAAATATTCCTTT
CACTATGGTAGGAAGACATCGCAGAGTGAAATTTGAAGATGTCATGAATTACAAGAAAAAAATGAAATTGAAACGGGAAC
AACTTCTTATAGATATGATGAAGTCTGATGAAGAATTAGGATTATATGATTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References