Detailed information of TA system TA127026

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 1076816..1077404
• Replicon: chromosome
• Accession: NZ_CP040813
• Organism: Oceanihabitans sp. IOP_32

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: FEZ18_RS04530
• Protein ID: WP_153267223.1
• Coordinates: 1077102..1077404 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FEZ18_RS04525
• Protein ID: WP_153267222.1
• Coordinates: 1076816..1077100 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FEZ18_RS04510	1072298..1073524	-	1227	WP_153267219.1	amino acid dehydrogenase	-
FEZ18_RS04515	1073664..1074731	-	1068	WP_153267220.1	anhydro-N-acetylmuramic acid kinase	-
FEZ18_RS04520	1074825..1075967	+	1143	WP_153267221.1	acyl-CoA dehydrogenase	-
FEZ18_RS04525	1076816..1077100	-	285	WP_153267222.1	putative addiction module antidote protein	Antitoxin
FEZ18_RS04530	1077102..1077404	-	303	WP_153267223.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FEZ18_RS04535	1077884..1080319	-	2436	WP_153267224.1	helix-turn-helix domain-containing protein	-
FEZ18_RS04540	1080531..1081045	+	515	Protein_887	nucleoside deaminase	-
FEZ18_RS04545	1081149..1081484	+	336	WP_153267225.1	arsenosugar biosynthesis-associated peroxidase-like protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-96)

Antitoxin

• Uncharacterized protein HI1420 (3-89)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11860.94 Da
• Isoelectric Point: 10.3575

>T127026 WP_153267223.1 NZ_CP040813:c1077404-1077102 [Oceanihabitans sp. IOP_32]
MIVIKKTSEFDKWIRKLKDIRAKSKILFRIQKLETDEHFGDCKPVGDGISEMRINYVKGYRAYFKEKDNKIVILLIGGDK
STQQKDIEKAKKIWNRIKED

Nucleotide

• Length: 303 bp

>T127026 NZ_CP040813:c1077404-1077102 [Oceanihabitans sp. IOP_32]
ATGATTGTCATTAAAAAGACATCTGAATTTGATAAGTGGATTAGAAAGCTGAAAGATATACGTGCGAAATCCAAAATACT
TTTCCGAATCCAGAAACTTGAAACTGATGAGCATTTTGGAGATTGTAAGCCTGTTGGAGATGGAATTAGTGAAATGCGAA
TTAATTATGTCAAAGGTTACAGAGCGTATTTCAAAGAAAAAGACAATAAAATCGTAATTCTTTTAATTGGTGGCGATAAA
TCTACTCAACAAAAAGATATCGAGAAAGCGAAAAAAATCTGGAACAGAATAAAAGAGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10077.67 Da
• Isoelectric Point: 4.7527

>AT127026 WP_153267222.1 NZ_CP040813:c1077100-1076816 [Oceanihabitans sp. IOP_32]
METTKFDIADYLDSEEMIAEYLNTVLEDGDSSDLIVAIGHIAKAIGMTKIAEKTGMSRPSLYKALSDGAKPQFGTIMKVL
KAIGGQINVKPISA

Nucleotide

• Length: 285 bp

>AT127026 NZ_CP040813:c1077100-1076816 [Oceanihabitans sp. IOP_32]
ATGGAAACAACTAAATTTGATATTGCAGACTATTTGGACAGCGAGGAAATGATTGCTGAATATCTGAATACAGTTCTTGA
AGATGGAGACAGTTCTGATTTGATAGTGGCAATCGGACATATAGCAAAGGCAATCGGAATGACTAAAATTGCGGAAAAAA
CTGGAATGAGCAGACCGAGTCTTTACAAGGCATTATCTGACGGAGCGAAACCGCAATTCGGAACAATAATGAAAGTGCTG
AAAGCGATAGGTGGACAAATAAACGTGAAACCAATTTCAGCGTAA