Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1205602..1206221 Replicon chromosome
Accession NZ_CP040805
Organism Escherichia fergusonii strain EFCF056

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag D8Z79_RS05770 Protein ID WP_125400517.1
Coordinates 1205602..1205820 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag D8Z79_RS05775 Protein ID WP_000344803.1
Coordinates 1205847..1206221 (-) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D8Z79_RS05740 1200662..1200973 - 312 WP_000409907.1 MGMT family protein -
D8Z79_RS05750 1201352..1201705 + 354 WP_000878140.1 DUF1428 domain-containing protein -
D8Z79_RS05755 1201747..1203297 - 1551 WP_001260376.1 EAL domain-containing protein -
D8Z79_RS05760 1203436..1203906 - 471 WP_002431406.1 YlaC family protein -
D8Z79_RS05765 1204512..1205492 - 981 WP_000019440.1 IS5-like element ISKpn26 family transposase -
D8Z79_RS05770 1205602..1205820 - 219 WP_125400517.1 hemolysin expression modulator Hha Toxin
D8Z79_RS05775 1205847..1206221 - 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
D8Z79_RS05780 1206724..1209873 - 3150 WP_001132493.1 multidrug efflux RND transporter permease subunit -
D8Z79_RS05785 1209896..1211089 - 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1204512..1205492 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-116)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T126999 WP_125400517.1 NZ_CP040805:c1205820-1205602 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSIWKFIR

Download         Length: 219 bp

>T126999 NZ_CP040805:c1205820-1205602 [Escherichia fergusonii]
ATGTCCGATAAGCCTTTAACCAAAACTGATTATTTGATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAACGTGT
CATCGAAAAAAATAAATACGAACTCTCTGACAATGAACTGGCGGTATTTTATTCAGCAGCTGATCACCGTCTCGCTGAAT
TGACCATGAATAAACTTTACGACAAGATCCCCTCCTCCATATGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT126999 WP_000344803.1 NZ_CP040805:c1206221-1205847 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT126999 NZ_CP040805:c1206221-1205847 [Escherichia fergusonii]
ATGGACGAATACTCACCAAAACGACATGATATCGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAATCTTGAAGAGAGCAACCATGGCTGGGTTAACGACCCAACCTCGGCTATCAATCTGCAGCTCAACGAACTGATTGAGC
ATATTGCAACCTTCGCACTTAATTACAAAATTAAGTATAATGAGGACAATAAGCTCATAGAGCAGATCGATGAATATCTG
GATGACACTTTTATGTTGTTCAGTAGTTATGGCATTAATACACAGGATTTACAGAAATGGCGAAAATCTGGAAACAGGCT
CTTCCGCTGTTTTGTTAACGCCACCAGGGCGAACCCTGTTAGTTTGTCGTGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References