Detailed information of TA system TA126998

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1075332..1076038
• Replicon: chromosome
• Accession: NZ_CP040805
• Organism: Escherichia fergusonii strain EFCF056

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: D8Z79_RS05135
• Protein ID: WP_125399798.1
• Coordinates: 1075670..1076038 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: D8Z79_RS05130
• Protein ID: WP_125399797.1
• Coordinates: 1075332..1075649 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D8Z79_RS05105	1070384..1071070	+	687	WP_047738081.1	WYL domain-containing protein	-
D8Z79_RS05110	1071143..1073986	+	2844	WP_125399793.1	Ag43/Cah family autotransporter adhesin	-
D8Z79_RS05115	1074128..1074592	+	465	WP_125399794.1	antirestriction protein	-
D8Z79_RS05120	1074601..1075083	+	483	WP_125399795.1	DNA repair protein RadC	-
D8Z79_RS05125	1075092..1075313	+	222	WP_125399796.1	DUF987 domain-containing protein	-
D8Z79_RS05130	1075332..1075649	+	318	WP_125399797.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
D8Z79_RS05135	1075670..1076038	+	369	WP_125399798.1	TA system toxin CbtA family protein	Toxin
D8Z79_RS05140	1076250..1076515	-	266	Protein_995	site-specific integrase	-
D8Z79_RS05145	1076656..1076757	-	102	WP_000662204.1	hypothetical protein	-
D8Z79_RS05150	1076893..1077204	-	312	Protein_997	hypothetical protein	-
D8Z79_RS05155	1077290..1078183	+	894	WP_000910705.1	LysR family transcriptional regulator	-
D8Z79_RS05160	1078218..1079207	-	990	WP_125399799.1	aldo/keto reductase	-
D8Z79_RS05165	1079234..1080085	-	852	WP_001195265.1	aldo/keto reductase	-
D8Z79_RS05170	1080366..1080845	-	480	WP_046076605.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1050539..1089289	38750

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13836.11 Da
• Isoelectric Point: 8.8576

>T126998 WP_125399798.1 NZ_CP040805:1075670-1076038 [Escherichia fergusonii]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLANAVNFLVKKYELVRIDRNGF
TLQERTPYLTVTDILHARRACGLMNSCSYREVSNIVLSRSRQ

Nucleotide

• Length: 369 bp

>T126998 NZ_CP040805:1075670-1076038 [Escherichia fergusonii]
ATGAAAACTCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTTTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATCACTCTGGCTAATGCCGTTAACTTTCTGGTAAAGAAATATGAGTTAGTTCGTATCGATCGCAATGGATTC
ACCTTACAGGAACGAACGCCATATTTGACTGTGACAGATATCCTTCATGCCAGGAGAGCATGCGGATTAATGAACAGTTG
TTCGTATCGGGAAGTAAGTAATATTGTTCTTAGCCGATCGCGGCAGTGA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11931.56 Da
• Isoelectric Point: 6.6246

>AT126998 WP_125399797.1 NZ_CP040805:1075332-1075649 [Escherichia fergusonii]
MSNMTWGLQRDITPRLGARLVQEGNRLHYLAERANITDKFSDAECLKLDVAFSHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 318 bp

>AT126998 NZ_CP040805:1075332-1075649 [Escherichia fergusonii]
ATGAGTAACATGACATGGGGCCTGCAGCGGGACATTACGCCACGCCTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCACTATCTGGCTGAGCGGGCAAATATCACCGATAAGTTTAGTGATGCCGAGTGTCTGAAGTTGGATGTCGCATTCTCGC
ATTTTATCAGTCAGATGGAATCAATGCTGACCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AATGGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATATATCGCCATTTATCCCACTCAACGCTAA