Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 153880..155126 Replicon plasmid pSAL813
Accession NZ_CP040803
Organism Streptococcus salivarius strain LAB813

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag FHI56_RS00785 Protein ID WP_149561087.1
Coordinates 153880..154650 (-) Length 257 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag FHI56_RS00790 Protein ID WP_149561088.1
Coordinates 154650..155126 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHI56_RS00770 150852..151835 + 984 WP_149561084.1 hypothetical protein -
FHI56_RS00775 151832..152545 - 714 WP_149561085.1 methyltransferase domain-containing protein -
FHI56_RS00780 152637..153533 + 897 WP_149561086.1 tyrosine-type recombinase/integrase -
FHI56_RS00785 153880..154650 - 771 WP_149561087.1 zeta toxin family protein Toxin
FHI56_RS00790 154650..155126 - 477 WP_149561088.1 helix-turn-helix domain-containing protein Antitoxin
FHI56_RS00795 155173..155466 - 294 WP_149561089.1 hypothetical protein -
FHI56_RS00800 155504..155887 - 384 WP_149561090.1 chemotaxis protein -
FHI56_RS00805 155884..156117 - 234 WP_149561091.1 hypothetical protein -
FHI56_RS00810 156168..157253 - 1086 WP_149561092.1 toprim domain-containing protein -
FHI56_RS00815 157263..157899 - 637 Protein_163 peptidylprolyl isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..183700 183700


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 29244.13 Da        Isoelectric Point: 7.5469

>T126990 WP_149561087.1 NZ_CP040803:c154650-153880 [Streptococcus salivarius]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTVDIPKKTAQLLKNKGYEVQLAIIATKPELSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELSIFERIQIYQRDRSCVYDSKENTTSAATVLHDLLFGEWNQVEKEML
KSGEERLKDLTNRNGG

Download         Length: 771 bp

>T126990 NZ_CP040803:c154650-153880 [Streptococcus salivarius]
ATGGAAATCCAAGATTATACTGATAGCGAATTCAAACATGCTTTAGCACGGAATCTTCGTTCTCTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCTGGCAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGCGATAGTTTTCGCTCTCAGCATCCACACTATTTAGAACTTCAGCAA
GAATATGGCAAAGATAGCGTTGAATACACCAAAGATTTTGCAGGGAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGGGATACAATCTTTTGATAGAGGGAACTCTACGAACAGTTGATATTCCAAAGAAAACGGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTAGCCATAATCGCAACAAAGCCCGAATTGTCCTATCTAAGCACCCTTATCCGATACGAAGAA
CTGTACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAACTATCTATCTTTGAAAGAATTCAAATTTATCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAACCGTTCTTCATGATTTACTATTTGGAGAATGGAATCAAGTTGAGAAAGAGATGCTT
AAATCTGGGGAAGAAAGATTGAAAGATTTAACCAATCGAAATGGTGGTTAG

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18314.79 Da        Isoelectric Point: 4.5045

>AT126990 WP_149561088.1 NZ_CP040803:c155126-154650 [Streptococcus salivarius]
MIGKNIKSLRKTHDLTQPEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDRQGISIDEESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT126990 NZ_CP040803:c155126-154650 [Streptococcus salivarius]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCCGAATTTGCACGGATTGTAGGTATTTC
ACGAAATAGTCTGAGTCGTTATGAAAATGGAACGAGTTCAGTCTCAACCGAATTAATAGACATCATTTGTCAGAAATTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGACAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGGGGTGCTAATCTACTATCTCGACTCTATCGTTATCAAGATAGACAGGGAATTAGCATTGATGAAGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGCGGCTATTTGGATGGAATTGAACGCATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References