Detailed information of TA system TA126982

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2082916..2083445
• Replicon: chromosome
• Accession: NZ_CP040801
• Organism: Staphylococcus aureus strain S15

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FHD66_RS10170
• Protein ID: WP_000621175.1
• Coordinates: 2082916..2083278 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: FHD66_RS10175
• Protein ID: WP_000948331.1
• Coordinates: 2083275..2083445 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FHD66_RS10150	2079895..2080665	-	771	WP_001041107.1	RNA polymerase sigma factor SigB	-
FHD66_RS10155	2080640..2081119	-	480	WP_001190825.1	anti-sigma B factor RsbW	-
FHD66_RS10160	2081121..2081447	-	327	WP_001052491.1	anti-sigma factor antagonist	-
FHD66_RS10165	2081566..2082567	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
FHD66_RS10170	2082916..2083278	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FHD66_RS10175	2083275..2083445	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
FHD66_RS10180	2083530..2084678	-	1149	WP_001280702.1	alanine racemase	-
FHD66_RS10185	2084744..2085103	-	360	WP_000581194.1	holo-ACP synthase	-
FHD66_RS10190	2085107..2085598	-	492	WP_001205915.1	PH domain-containing protein	-
FHD66_RS10195	2085585..2087168	-	1584	WP_001294642.1	PH domain-containing protein	-
FHD66_RS10200	2087161..2087640	-	480	WP_001287083.1	hypothetical protein	-
FHD66_RS10205	2087849..2088409	-	561	WP_001092405.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T126982 WP_000621175.1 NZ_CP040801:c2083278-2082916 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T126982 NZ_CP040801:c2083278-2082916 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT126982 WP_000948331.1 NZ_CP040801:c2083445-2083275 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT126982 NZ_CP040801:c2083445-2083275 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1