Detailed information of TA system TA126976

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 865948..866480
• Replicon: chromosome
• Accession: NZ_CP040801
• Organism: Staphylococcus aureus strain S15

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: FHD66_RS04095
• Protein ID: WP_001103942.1
• Coordinates: 866160..866480 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: FHD66_RS04090
• Protein ID: WP_001058486.1
• Coordinates: 865948..866157 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FHD66_RS04045	860966..862186	-	1221	WP_000266157.1	site-specific integrase	-
FHD66_RS04050	862275..863003	-	729	WP_000733774.1	staphylococcal enterotoxin type K	-
FHD66_RS04055	863027..863755	-	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
FHD66_RS04060	863826..864257	-	432	WP_001228759.1	hypothetical protein	-
FHD66_RS04065	864274..864732	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
FHD66_RS04070	864744..865076	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
FHD66_RS04075	865269..865532	+	264	WP_000243851.1	helix-turn-helix domain-containing protein	-
FHD66_RS04080	865525..865797	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
FHD66_RS04085	865809..865955	+	147	WP_000784875.1	hypothetical protein	-
FHD66_RS04090	865948..866157	+	210	WP_001058486.1	hypothetical protein	Antitoxin
FHD66_RS04095	866160..866480	+	321	WP_001103942.1	DUF1474 family protein	Toxin
FHD66_RS04100	866544..867413	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
FHD66_RS04105	867430..868899	+	1470	WP_000390454.1	virulence-associated E family protein	-
FHD66_RS04110	869185..869547	+	363	WP_001039168.1	hypothetical protein	-
FHD66_RS04115	869549..869833	+	285	WP_000998181.1	hypothetical protein	-
FHD66_RS04120	869830..870471	+	642	WP_001019764.1	hypothetical protein	-
FHD66_RS04125	870988..871329	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp / selk / selq / seb	831890..876281	44391

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T126976 WP_001103942.1 NZ_CP040801:866160-866480 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T126976 NZ_CP040801:866160-866480 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT126976 WP_001058486.1 NZ_CP040801:865948-866157 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT126976 NZ_CP040801:865948-866157 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4