Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 848251..848728 Replicon chromosome
Accession NZ_CP040801
Organism Staphylococcus aureus strain S15

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag FHD66_RS03950 Protein ID WP_000052076.1
Coordinates 848251..848439 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag FHD66_RS03955 Protein ID WP_001059690.1
Coordinates 848468..848728 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FHD66_RS03915 843936..844136 + 201 WP_001059082.1 cold-shock protein -
FHD66_RS03920 844635..844853 - 219 WP_000005888.1 hypothetical protein -
FHD66_RS03925 844915..845199 - 285 WP_001004397.1 hypothetical protein -
FHD66_RS03930 845287..845601 - 315 Protein_759 hypothetical protein -
FHD66_RS03935 845694..846986 + 1293 WP_000777467.1 IS21 family transposase -
FHD66_RS03940 846979..847740 + 762 WP_001066124.1 IS21-like element helper ATPase IstB -
FHD66_RS03945 847800..848063 - 264 Protein_762 hypothetical protein -
FHD66_RS03950 848251..848439 - 189 WP_000052076.1 hypothetical protein Toxin
FHD66_RS03955 848468..848728 - 261 WP_001059690.1 hypothetical protein Antitoxin
FHD66_RS03960 849069..849272 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
FHD66_RS03965 849269..849505 - 237 WP_000368687.1 hypothetical protein -
FHD66_RS03970 849730..850311 + 582 WP_001140697.1 phosphoglycerate mutase family protein -
FHD66_RS03975 850384..851001 - 618 WP_000255554.1 LysE/ArgO family amino acid transporter -
FHD66_RS03980 851157..851651 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
FHD66_RS03985 852050..852472 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
FHD66_RS03990 852620..853336 + 717 WP_000150029.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp / selk / selq / seb 831890..876281 44391
- flank IS/Tn - - 846976..847740 764


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T126975 WP_000052076.1 NZ_CP040801:c848439-848251 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T126975 NZ_CP040801:c848439-848251 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT126975 WP_001059690.1 NZ_CP040801:c848728-848468 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT126975 NZ_CP040801:c848728-848468 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References