Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2509327..2509938 Replicon chromosome
Accession NZ_CP040799
Organism Xylella fastidiosa subsp. fastidiosa strain Bakersfield-1

Toxin (Protein)


Gene name relE Uniprot ID Q879T9
Locus tag FG899_RS11325 Protein ID WP_011098375.1
Coordinates 2509639..2509938 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag FG899_RS11320 Protein ID WP_004085003.1
Coordinates 2509327..2509635 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG899_RS11290 2505897..2506658 - 762 WP_004090267.1 Bax inhibitor-1/YccA family protein -
FG899_RS11315 2507850..2509253 + 1404 WP_011098374.1 hypothetical protein -
FG899_RS11320 2509327..2509635 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
FG899_RS11325 2509639..2509938 - 300 WP_011098375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FG899_RS11330 2510026..2510571 + 546 WP_011098376.1 hypothetical protein -
FG899_RS11335 2510583..2510726 + 144 WP_155115087.1 hypothetical protein -
FG899_RS11340 2510879..2511259 - 381 WP_004089371.1 DUF596 domain-containing protein -
FG899_RS11345 2511264..2512394 - 1131 WP_012382788.1 DUF769 domain-containing protein -
FG899_RS11350 2512702..2513082 - 381 WP_004087391.1 DUF596 domain-containing protein -
FG899_RS11355 2513094..2514668 - 1575 Protein_2170 DUF637 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2460118..2516204 56086


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11378.17 Da        Isoelectric Point: 10.3861

>T126974 WP_011098375.1 NZ_CP040799:c2509938-2509639 [Xylella fastidiosa subsp. fastidiosa]
MTYTLKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

>T126974 NZ_CP040799:c2509938-2509639 [Xylella fastidiosa subsp. fastidiosa]
ATGACCTACACGCTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGCGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTAGAGGATTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT126974 WP_004085003.1 NZ_CP040799:c2509635-2509327 [Xylella fastidiosa subsp. fastidiosa]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp

>AT126974 NZ_CP040799:c2509635-2509327 [Xylella fastidiosa subsp. fastidiosa]
GTGACCATCACAAAGAAAATCAATGTCTCCGAACTGCCAGAGTTCGATGCCGCCGAATACCTGAACAGCGAAGAGGAGGT
AGCCGCGTATCTCACGGCTGTTCTTGAAGAAAACGATCCAGCACTGTTAGCGGCTGCGCTTGGTGACATTGCCCGTTCAC
GTGGTATGTCTCAGATTGCGAAGGATTCTGGCATCACGCGGGAAGCTCTATACAAGGCCCTTCGGCCTGGTAGTGAACCA
CGCTTCGATACGATAAGCCGCGTCTGTACCGCCCTAGGTATACGTCTAGTAGCGCAACCAATGCATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q879T9

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References