Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1581196..1581782 Replicon chromosome
Accession NZ_CP040799
Organism Xylella fastidiosa subsp. fastidiosa strain Bakersfield-1

Toxin (Protein)


Gene name hicA Uniprot ID Q87BV5
Locus tag FG899_RS07275 Protein ID WP_004089517.1
Coordinates 1581528..1581782 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID B2I6C9
Locus tag FG899_RS07270 Protein ID WP_004085025.1
Coordinates 1581196..1581531 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FG899_RS07240 1576795..1577649 - 855 WP_011098055.1 iron-sulfur cluster carrier protein ApbC -
FG899_RS07245 1578141..1578914 + 774 WP_004089528.1 3-deoxy-manno-octulosonate cytidylyltransferase -
FG899_RS07250 1578911..1579375 + 465 WP_011098056.1 low molecular weight phosphotyrosine protein phosphatase -
FG899_RS07255 1579362..1580075 - 714 WP_011098057.1 site-specific DNA-methyltransferase -
FG899_RS07260 1580426..1580707 + 282 WP_011098058.1 type II toxin-antitoxin system RelE/ParE family toxin -
FG899_RS07265 1580717..1581016 + 300 WP_004089519.1 HigA family addiction module antidote protein -
FG899_RS07270 1581196..1581531 - 336 WP_004085025.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FG899_RS07275 1581528..1581782 - 255 WP_004089517.1 type II toxin-antitoxin system HicA family toxin Toxin
FG899_RS07280 1581835..1582533 - 699 WP_011098059.1 hypothetical protein -
FG899_RS07285 1582662..1583123 - 462 WP_011098060.1 hypothetical protein -
FG899_RS07290 1583120..1583884 - 765 WP_004090689.1 hypothetical protein -
FG899_RS07295 1583790..1584896 - 1107 WP_012382665.1 YdaU family protein -
FG899_RS07300 1584893..1585192 - 300 WP_080513037.1 hypothetical protein -
FG899_RS07305 1585191..1585668 + 478 Protein_1393 conjugal transfer protein -
FG899_RS07310 1585674..1586279 + 606 WP_004091108.1 conjugal transfer protein TrbN -
FG899_RS07315 1586368..1586727 + 360 Protein_1395 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1554284..1601052 46768


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-80)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9639.14 Da        Isoelectric Point: 11.2766

>T126973 WP_004089517.1 NZ_CP040799:c1581782-1581528 [Xylella fastidiosa subsp. fastidiosa]
MKRKHAKTLSAIYTRPVSANIQWRDIEALFVELGAKVEEREGSRMLVRLFGERRIFHRPHPSPNTDKGAVESIRAWLKSN
GVTP

Download         Length: 255 bp

>T126973 NZ_CP040799:c1581782-1581528 [Xylella fastidiosa subsp. fastidiosa]
ATGAAGCGTAAGCACGCTAAAACTCTCAGCGCTATATACACACGCCCTGTTTCGGCCAACATTCAATGGCGCGATATTGA
AGCGCTGTTCGTGGAGCTTGGAGCGAAAGTAGAAGAACGTGAAGGTTCTCGTATGTTGGTGCGACTGTTCGGTGAACGTC
GGATATTCCACCGGCCCCACCCTTCTCCTAACACTGACAAGGGTGCTGTTGAATCAATCCGAGCTTGGTTGAAATCGAAC
GGAGTTACACCATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12324.07 Da        Isoelectric Point: 5.6556

>AT126973 WP_004085025.1 NZ_CP040799:c1581531-1581196 [Xylella fastidiosa subsp. fastidiosa]
MKNIMTIESFKAIITYDPEIDMFRGEFVGINGGADFYAKDLKGLRREGAISLKVFLEACKEDSVEPRKCYSGKFNARISP
ELHALASEAAAAQGISLNQFVEQAIQHEVHT

Download         Length: 336 bp

>AT126973 NZ_CP040799:c1581531-1581196 [Xylella fastidiosa subsp. fastidiosa]
ATGAAGAACATCATGACTATTGAGAGCTTTAAAGCCATCATTACCTATGATCCGGAGATCGACATGTTTCGCGGTGAATT
TGTGGGTATCAATGGTGGTGCTGATTTCTATGCAAAAGACCTTAAGGGTCTTCGTCGAGAAGGAGCTATTTCTCTGAAGG
TATTTTTGGAAGCCTGCAAAGAAGATAGCGTGGAACCACGTAAATGCTACTCAGGGAAGTTCAATGCAAGGATTTCTCCT
GAACTGCATGCTTTGGCTTCTGAAGCCGCAGCAGCACAGGGCATCAGTTTGAACCAATTTGTAGAACAAGCGATTCAGCA
TGAAGTCCACACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87BV5

Antitoxin

Source ID Structure
AlphaFold DB A0A060HAK5

References