Detailed information of TA system TA126972

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1392119..1392596
• Replicon: chromosome
• Accession: NZ_CP040799
• Organism: Xylella fastidiosa subsp. fastidiosa strain Bakersfield-1

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: Q87CA4
• Locus tag: FG899_RS06420
• Protein ID: WP_011097988.1
• Coordinates: 1392330..1392596 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A7G7TPD2
• Locus tag: FG899_RS06415
• Protein ID: WP_004091377.1
• Coordinates: 1392119..1392346 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FG899_RS06375	1387246..1388391	-	1146	WP_011097984.1	baseplate J/gp47 family protein	-
FG899_RS06380	1388490..1388786	+	297	WP_004089252.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FG899_RS06385	1388790..1389095	+	306	WP_004089254.1	putative addiction module antidote protein	-
FG899_RS06390	1389106..1389459	-	354	WP_011097986.1	hypothetical protein	-
FG899_RS06395	1389456..1390097	-	642	WP_004090764.1	hypothetical protein	-
FG899_RS06400	1390094..1390924	-	831	WP_004090766.1	hypothetical protein	-
FG899_RS06405	1390921..1391238	-	318	WP_011097873.1	hypothetical protein	-
FG899_RS06410	1391238..1392008	-	771	WP_004090769.1	hypothetical protein	-
FG899_RS06415	1392119..1392346	+	228	WP_004091377.1	hypothetical protein	Antitoxin
FG899_RS06420	1392330..1392596	+	267	WP_011097988.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FG899_RS06425	1392607..1394496	-	1890	WP_011097989.1	hypothetical protein	-
FG899_RS06430	1394453..1394617	-	165	WP_014607750.1	hypothetical protein	-
FG899_RS06435	1394644..1395066	-	423	WP_004085005.1	hypothetical protein	-
FG899_RS06440	1395063..1395500	-	438	WP_011097990.1	DUF3277 family protein	-
FG899_RS06445	1395510..1395731	-	222	Protein_1225	DUF3383 family protein	-
FG899_RS06450	1395760..1396965	-	1206	Protein_1226	transposase	-
FG899_RS06455	1396959..1397564	-	606	Protein_1227	IS607 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1385441..1403740	18299
	-	flank	IS/Tn	-	-	1396959..1397180	221

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10163.79 Da
• Isoelectric Point: 10.6086

>T126972 WP_011097988.1 NZ_CP040799:1392330-1392596 [Xylella fastidiosa subsp. fastidiosa]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR

Nucleotide

• Length: 267 bp

>T126972 NZ_CP040799:1392330-1392596 [Xylella fastidiosa subsp. fastidiosa]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAGCTCGACAAGCACATGGCGCGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAACCCACGCAGCAGTGGTAAAGCATTAACCGGACCACTTGGCGGCT
TTTGGCGTTATCGTGTTGGTGATTTCCGGGTCGTCTGCGCCATTCAAGATAGCGTTTTGCGCGTCCTTGTAGTGCGTGTT
GGTCACCGGGGTGAGATTTACCGATAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8615.63 Da
• Isoelectric Point: 5.0958

>AT126972 WP_004091377.1 NZ_CP040799:1392119-1392346 [Xylella fastidiosa subsp. fastidiosa]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Nucleotide

• Length: 228 bp

>AT126972 NZ_CP040799:1392119-1392346 [Xylella fastidiosa subsp. fastidiosa]
ATGGCGACTTCGATTCGCCTCTCTCCTGAAATGGAGCAAAGGCTGAACTCTCTTGCCTCCCATACGGGACGCACAAAGGC
TTACTACCTACGTGAAATCATTGAGCATGGCATTGAGGAAATGGAGGATTACTACCTTGCTGCCGATGTGTTGGAACGTG
TCCGTCATGGACAAGAACAGGTGCATTCTGCTGCCGATGTGAGGAAAACGCTTGGCCTGGACGATTGA

Structures

Toxin

• AlphaFold DB: A0A060HDH1

Antitoxin

• AlphaFold DB: A0A7G7TPD2