Detailed information of TA system TA126970

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-dinJ/YafQ-RelB
• Location: 1307205..1307736
• Replicon: chromosome
• Accession: NZ_CP040799
• Organism: Xylella fastidiosa subsp. fastidiosa strain Bakersfield-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q87CH1
• Locus tag: FG899_RS05945
• Protein ID: WP_004090909.1
• Coordinates: 1307455..1307736 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Q87CH2
• Locus tag: FG899_RS05940
• Protein ID: WP_004090907.1
• Coordinates: 1307205..1307468 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FG899_RS05915	1302431..1303609	-	1179	WP_011097931.1	phage tail sheath family protein	-
FG899_RS05920	1303674..1305266	-	1593	WP_012382617.1	tail fiber domain-containing protein	-
FG899_RS05925	1305274..1305831	-	558	WP_011097610.1	phage tail protein I	-
FG899_RS05930	1305824..1306717	-	894	WP_011097611.1	baseplate J/gp47 family protein	-
FG899_RS05935	1306717..1307055	-	339	WP_004090694.1	GPW/gp25 family protein	-
FG899_RS05940	1307205..1307468	+	264	WP_004090907.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FG899_RS05945	1307455..1307736	+	282	WP_004090909.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FG899_RS05950	1307773..1308360	-	588	WP_011097612.1	phage baseplate assembly protein V	-
FG899_RS05955	1308357..1308899	-	543	WP_011097613.1	hypothetical protein	-
FG899_RS05960	1308875..1309396	-	522	WP_011097614.1	hypothetical protein	-
FG899_RS05965	1309393..1309716	-	324	WP_012382618.1	hypothetical protein	-
FG899_RS05970	1309716..1309976	-	261	WP_012382619.1	hypothetical protein	-
FG899_RS05975	1309994..1311868	-	1875	WP_012382620.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1293792..1340514	46722

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10936.37 Da
• Isoelectric Point: 7.2205

>T126970 WP_004090909.1 NZ_CP040799:1307455-1307736 [Xylella fastidiosa subsp. fastidiosa]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVLEALTCDHPLEPRHHDHALTGDWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Nucleotide

• Length: 282 bp

>T126970 NZ_CP040799:1307455-1307736 [Xylella fastidiosa subsp. fastidiosa]
ATGCGGAGGATTAGCCAGACTGGCCAATTCAAGCGCGACTACAAGCGCGAAGCTAAGGGCCAGCATCGCGCCACGCTTGA
TGAGGAACTGATACACGTCTTGGAAGCCTTGACCTGTGATCATCCGTTGGAGCCACGCCACCACGATCACGCACTAACTG
GCGACTGGAAAGATCACCGTGATTGCCACATCAAACCCGACTTGGTACTGATATACCGGAAGCCCGACAACGAGACATTG
CAGCTCGTGCGCATTGGCTCACACAGCGAACTAGGTTTGTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9495.95 Da
• Isoelectric Point: 5.6033

>AT126970 WP_004090907.1 NZ_CP040799:1307205-1307468 [Xylella fastidiosa subsp. fastidiosa]
MSANAVVRARVDAHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNETTIAAMREARAGHLKSFDSIEALM
ADLHAED

Nucleotide

• Length: 264 bp

>AT126970 NZ_CP040799:1307205-1307468 [Xylella fastidiosa subsp. fastidiosa]
ATGTCTGCAAACGCAGTTGTCCGTGCCCGCGTTGACGCGCACATCAAAGAAGAAGCATCAACCGTGCTGGCGACGATGGG
CCTAAGCGTGTCTGATGCGTTCCGTATGATGCTGACCCGCATTGCCCGCGAGAAGGCGCTGCCGTTCGAGCCGCTGGTGC
CGAACGAAACTACCATCGCAGCCATGCGTGAAGCCCGTGCTGGTCACCTCAAGAGCTTTGATAGTATTGAGGCGCTCATG
GCGGACTTGCATGCGGAGGATTAG

Structures

Toxin

• AlphaFold DB: Q87CH1

Antitoxin

• AlphaFold DB: Q87CH2