Detailed information of TA system TA126967

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsR-graA/MqsR-HigA
• Location: 457491..458156
• Replicon: chromosome
• Accession: NZ_CP040799
• Organism: Xylella fastidiosa subsp. fastidiosa strain Bakersfield-1

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: Q87EE2
• Locus tag: FG899_RS01940
• Protein ID: WP_004090696.1
• Coordinates: 457854..458156 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: FG899_RS01935
• Protein ID: WP_004085172.1
• Coordinates: 457491..457766 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FG899_RS01905	453622..454341	-	720	Protein_343	phage late control D family protein	-
FG899_RS01910	454241..455212	-	972	WP_011097609.1	hypothetical protein	-
FG899_RS01915	455220..455777	-	558	WP_011097610.1	phage tail protein I	-
FG899_RS01920	455770..456663	-	894	WP_011097611.1	baseplate J/gp47 family protein	-
FG899_RS01925	456663..457001	-	339	WP_004090694.1	GPW/gp25 family protein	-
FG899_RS01930	457199..457480	+	282	WP_004090695.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FG899_RS01935	457491..457766	+	276	WP_004085172.1	HigA family addiction module antidote protein	Antitoxin
FG899_RS01940	457854..458156	+	303	WP_004090696.1	type II toxin-antitoxin system MqsR family toxin	Toxin
FG899_RS01945	458159..458560	+	402	WP_004090697.1	type II toxin-antitoxin system MqsA family antitoxin	-
FG899_RS01950	458629..459216	-	588	WP_011097612.1	phage baseplate assembly protein V	-
FG899_RS01955	459213..459755	-	543	WP_011097613.1	hypothetical protein	-
FG899_RS01960	459731..460252	-	522	WP_011097614.1	hypothetical protein	-
FG899_RS01965	460249..460572	-	324	WP_011097935.1	hypothetical protein	-
FG899_RS01970	460572..460832	-	261	WP_011097616.1	hypothetical protein	-
FG899_RS01975	460850..462724	-	1875	WP_011097617.1	phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	445797..469711	23914

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-99)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-64)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10948.71 Da
• Isoelectric Point: 8.0251

>T126967 WP_004090696.1 NZ_CP040799:457854-458156 [Xylella fastidiosa subsp. fastidiosa]
MEKGTSHYKLPVVKALVKAGKVRATATAYQGARELGIKDLTGMCTVVLALTSADFYKSMTTYADHTVFQDVYHAKTASGD
EVYLKLTVIDDVLIVSFKEL

Nucleotide

• Length: 303 bp

>T126967 NZ_CP040799:457854-458156 [Xylella fastidiosa subsp. fastidiosa]
ATGGAGAAAGGCACATCTCACTATAAGCTACCAGTCGTCAAAGCCTTGGTGAAAGCTGGCAAGGTCAGGGCTACAGCGAC
CGCCTACCAAGGAGCACGTGAGCTCGGCATCAAAGATTTAACTGGAATGTGCACCGTTGTCTTGGCGCTCACGTCTGCCG
ACTTCTACAAGAGCATGACGACCTACGCGGATCACACAGTATTCCAGGATGTGTACCACGCCAAGACGGCAAGCGGTGAT
GAGGTGTACCTGAAGTTAACTGTCATTGATGACGTGTTGATTGTTTCCTTCAAGGAGTTATGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10072.68 Da
• Isoelectric Point: 10.2184

>AT126967 WP_004085172.1 NZ_CP040799:457491-457766 [Xylella fastidiosa subsp. fastidiosa]
MKRMHNPAHPGEVLREYLGELTVTNAAAKLGVSRVALSRILNGTNGISADMALRLEDALGTSAEMWAAMQFKYDLWVASQ
QPRPKITRLHV

Nucleotide

• Length: 276 bp

>AT126967 NZ_CP040799:457491-457766 [Xylella fastidiosa subsp. fastidiosa]
ATGAAACGTATGCACAATCCCGCACATCCAGGTGAAGTGTTGCGTGAGTATCTTGGTGAGCTCACTGTGACCAATGCGGC
TGCAAAGCTAGGCGTCAGCCGTGTGGCTTTGTCGCGTATTCTCAATGGTACCAATGGCATCTCTGCCGATATGGCCCTTC
GCCTGGAAGATGCGCTTGGCACCAGTGCAGAGATGTGGGCAGCCATGCAGTTCAAGTATGACCTGTGGGTTGCTAGTCAG
CAGCCACGCCCGAAGATCACGCGCCTTCATGTTTAG

Structures

Toxin

• AlphaFold DB: Q87EE2